Flavonoids

Flavonoid Shampoo is Chemical Free and Nourishing

April 16, 2020 Cannabis, Flavonoids, Pharmaceutical

A Completely Polyherbal Conditioning and Antioxidant Shampoo- A Phytochemical Study and Pharmaceutical Evaluation

In Summary

Researchers have recently developed a conditioning shampoo using flavonoids and a foaming agent that nourishes hair and provides antimicrobial effects. Generic storebought shampoos have been found to have detrimental effects on hair follicles and scalp health, often stripping them of their natural oils and causing dryness and irritation. The leaves of Salix babylonica L., Ziziphus spina-christi L. (Willd), and Glycyrrhiza glabra rhizomes were used to make an extract rich in flavonoids and other phenolic compounds. The extract was altered until the ideal microbial effect was found and then combined with a foaming agent, forming the natural shampoo. Future research should continue to develop a line of all-natural cosmetic products for those who are sensitive or wish to avoid chemicals.

This piece reflects the current trend of the beauty industry and the apparent future of cosmetics as all-natural products. Researchers and estheticians will likely create products that appease trend-followers desire to endorse all-natural products while also enjoying the effects of the products that have been enhanced by modern science. The cannabis industry, will all of the benefits provided by cannabinoids, flavonoids, and terpenes, would do well to capitalize on the rapidly growing and fiercely loyal beauty community by promoting natural products that are as effective as they are trendy.

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Flavonoids in Peacock Moss Found to be AntiHyperglycemic

April 14, 2020 Flavonoids

The bioflavonoids as protein tyrosine phosphatase 1B inhibitors from Selaginella uncinata and their antihyperglycemic action

In Summary

Researchers have recently revealed the antihyperglycemic effects of flavonoids extracted from peacock moss. Nine biflavonoids were extracted from peacock moss (Selaginella uncinata) and examined for their effect on protein tyrosine phosphatase 1B, which is a regulatory protein of the insulin pathway, and were all found to have an inhibitory effect. Each of the flavonoids was found to be an allosteric modulator with a highly efficient binding mechanism. The antihyperglycemic effects of these flavonoids may lead to novel treatments for high blood sugar and may lend itself to regulating symptoms of diabetes.

Highlighted in this study is the possible therapeutic benefits of chemicals produced by cannabis other than cannabinoids, such as flavonoids, due to their antioxidant and protective properties. Flavonoids and terpenes are often found in common fruits and fruits and other common crops, like moss, already harvested in the United States are full of polyphenols that have many therapeutic benefits. Cannabis plants are full of flavonoids and terpenes that have been featured in recent literature as novel drug therapies but polyphenols can also be found in a myriad of crops that are still undervalued in western medicine and warrant further investigation.

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Flavonoids and Other Herbal Compounds in Anhua Tea Provide Neuroprotective Effects

April 9, 2020 Cannabis, Flavonoids

Neuroprotective effect of catechins derivatives isolated from Anhua dark tea on NMDA-induced excitotoxicity in SH-SY5Y cells

In Summary

Researchers have found that catechins and flavonoids found in Anhua tea provide neuroprotective effects against NDMA-induced excitotoxicity. NDMA receptors are part of the glutaminergic system; glutamate is the most abundant excitatory neurotransmitter in the human nervous system. During dysregulation of the glutaminergic system, an excess of glutamate can cause excitotoxicity which can lead to brain injury and cell apoptosis. The compiled data suggests that at least one of the naturally occurring compounds in Anhua tea is effective at protecting against NMDA-induced brain injury and cell apoptosis when given as a dietary supplement.

This research may prove beneficial for developing preventative therapies for Alzheimer’s disease, depression, stroke, epilepsy, and schizophrenia. Anhua tea has been used in eastern medicine for centuries and like other herbal compounds in eastern medicine, has recently been featured in modern research. Considering the myriad of potential therapies that have been suggested due to the recently found medical benefits of herbal medicine, westerners should begin taking advantage of flavonoids and the like compounds that have been booming in Chinese medicine. Flavonoids and terpenes are two categories of naturally occurring compounds that have, so far, shown promise as novel therapies for treatment-resistant ailments, yet are still incredibly under-researched. Explore more of our blog to find out what other medical benefits can be provided by flavonoids and terpenes.

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A Flavonoid Improves Neurocognitive Function and Mood in Seniors

March 17, 2020 Flavonoids, Neurocognitive Functioning, Placebo-Controlled, Seniors

A highly bioavailable curcumin extract improves neurocognitive function and mood in healthy older people- A 12-week randomized, double-blind, placebo-controlled trial

In Summary

A recent study has revealed the neurocognitive benefits of curcumin, a flavonoid isolated from turmeric. Curcumin extract was given to a cohort of healthy, aged individuals over a 12-week period. At the end of that period improved working memory, as well as reduced fatigue and stress reactivity, were all recorded effects. A preceding study recorded similar effects from curcumin extract that were seen at 4 weeks, suggesting that the supplement works quickly and maintains effectiveness. The extract, also known as Longvida^TM, improves overall hippocampal function and may prevent cognitive decline in aging individuals.

The desire to prevent neurocognitive decline is evergrowing as individuals continue to be plagued by diagnoses of dementia, Alzheimer’s, and numerous other neurocognitive diseases associated with aging. Compounds found in cannabis plants, various cannabinoids, flavonoids similar to curcumin, and terpenes, have been found to have neuroprotective effects. If preventative measures can be found to delay or completely eradicate neurodegenerative diseases it would lessen the economic burden posed by such patients, ease the lives of caretakers, and allow patients for freedom and a better quality of life. Further research should continue to focus on this line of work.

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Flavonoids Help Post-Workout Recovery in Endurance Athletes

March 6, 2020 Athletics, Flavonoids

Mixed Flavonoid Supplementation Attenuates Post-Exercise Plasma Levels of Protein Carbonyls and 4-Hydroxynonenal Protein Adducts Levels in Endurance Athletes (P23-009-19)

In Summary

Researchers have recently exposed the benefits of flavonoid supplements in endurance athletes. The mixed flavonoid supplement included quercetin, a flavonoid found in cannabis plants, and was able to mitigate the oxidative stress that occurs post-exercise in endurance athletes. The other flavonoids harnessed from green tea and bilberry extracts were also included in the antioxidant supplement whose combined efforts were able to minimize the damaging effects of oxidation. The development of these all-natural supplements may provide a beneficial way for athletes to recover from intense workouts while complying with regulations set by sports associations.

Novel recovery techniques like the one featured in this paper are important for recovering athletes trying to navigate harsh regulations set by overarching organizations. Cannabidiol (CBD) has been praised and is well known for its therapeutic techniques, yet many athletes fear to utilize CBD during recovery from an injury or intense workout because it lays in a moral grey area for most athletic organizations. For example, tetrahydrocannabinol (THC) is a banned substance according to the NCAA and although CBD is not the NCAA still warns against its use due to the possibility of THC contamination. Athletes should be mindful to check with their organization for cannabis rules and ensure the products they use during recovery, such as CBD, come from a trusted source.

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Prenatal Exposure to Flavonoid Baicalein Shows Conflicting Results

March 1, 2020 Animal Model, Flavonoids

Baicalein, a flavonoid causes prolonged estrus and suppressed fertility output upon prenatal exposure in female mice

In Summary

Flavonoids are found in large quantities in flax seeds and plants including cannabis. There is conflicting evidence as to the effects of prenatal exposure to excessive quantities of flavonoids. The flavonoid baicalein has been used in Asian countries as herbal medicine to treat conditions including memory disorders, gastrointestinal dysfunction, and Parkinson’s disease. However, in excessive quantities, flavonoids have been shown to disrupt hormone production and function. Researchers interested in the effects of prenatal exposure to the baicalein administered the flavonoid to pregnant rats and observed effects on mothers and offspring. No signs of toxicity were observed. Exposed offspring weighed significantly less than control offspring, however, exposed female offspring also saw enhanced fertility .

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High Flavonoid Content of Dry Birch Leaves Makes for High Antioxidant Potential

February 28, 2020 Anti-inflammatory properties, Antioxidant, Flavonoids, Non-Cannabis Plant

Antioxidant Activity of Dry Birch (Betula Pendula) Leaves Extract

In Summary

Plants with high flavonoid content, including but not limited to cannabis, tend to exhibit vast health benefits, including but not limited to anti-inflammation, anti-oxidant, anti-cancer, and anti-bacterial applications.

The medicinal use of Betula Pendula, or dry birch leaves dates back as far as Ancient Greece. Birch leaf extracts exhibit anticancer, antifungal, diuretic, antimicrobial, antiflammatory properties, and more. In order to determine the antioxidant capabilities of birch leaf extract, researchers determined flavonoid content in leaves and administered extracts to rats and subsequently analyzed the antioxidant potential of the rats’ plasma. The leaves had a total flavonoid content of 42.5 milligrams per gram and short-term application of extract to rats resulted in enhanced antioxidant potential in their plasma. Chronic application was not as effective as short-term application. Overall, the high flavonoid content of dry birch leaves allows for high antioxidant potential, as well as a range of other health benefits.

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Flavonoids Improve Lipid and Glucose Metabolism in Dyslipidemic Overweight Subjects

February 17, 2020 Flavonoids, Obesity

Three‐arm, placebo‐controlled, randomized clinical trial evaluating the metabolic effect of a combined nutraceutical containing a bergamot standardized flavonoid extract in dyslipidemic overweight subjects

In Summary

A recent study has revealed the therapeutic benefits of flavonoids from bergamot fruits improve lipid and glucose metabolism in dyslipidemic overweight subjects. Dyslipidemic individuals have elevated levels of cholesterol and fats in their blood which increases their risk of suffering from a stroke or heart attack. The flavonoids present in bergamot extracts lowered total cholesterol, systemic inflammation, and a myriad of other chemicals that pose health risks, such as tumor necrosis factor-alpha (TNF-alpha). This study provides evidence that the flavonoids present in bergamot extracts may benefit those suffering from high cholesterol by lowering their risk of stroke and heart attack.

This article highlights the potential health benefits of flavonoids. Flavonoids are commonly found among cannabis plants and various other crops that are already produced at a commercial level. Flavonoids are extremely understudied when considering their known therapeutic potential as well as how cost efficient producing flavonoid-containing supplements would be. Extracts and diets containing elevated levels of flavonoids would be a simple and effective method of providing a myriad of health benefits into users everyday lives, which warrants further research and development.

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Flavonoid-Like Compound, Resveratrol, Treats Non-Alcohol Liver Disease

January 30, 2020 Alcohol, endocannabinoid system, Flavonoids, High-Fat Diet

Resveratrol attenuates high-fat diet-induced non-alcoholic steatohepatitis by maintaining gut barrier integrity and inhibiting gut inflammation through regulation of the endocannabinoid system

In Summary

A recent study has discovered that resveratrol treats high-fat diet-induced non-alcoholic steatohepatitis (NASH) by modulating the endocannabinoid system. Resveratrol is a flavonoid-like compound found in grapes and berries that acts as an antagonist on cannabinoid receptors. Due to its antagonistic effect on the endocannabinoid system the compound has similar anti-inflammatory properties to cannabidiol and reduces inflammation associated with NASH, as well as maintaining gut barrier integrity. Further research should conclude the efficacy of this treatment.

Highlighted in this study is the possible therapeutic benefits of polyphenols, such as flavonoids, due to their antioxidant and protective properties. Resveratrol is a non-flavonoid polyphenol found in common fruits, but fruits and other common crops already harvested in the United States are full of polyphenols that have therapeutic benefits. Cannabis plants are full of flavonoids that have been featured in recent literature as novel drug therapies but polyphenols found in a myriad of crops are still undervalued in western medicine and warrant further investigation.

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Atriplex Tatarica Flavonoids Show Anti-Bacterial and Anti-Biofilm Activity

January 15, 2020 Anti-Bacterial, Antibiotics, Flavonoids, Non-Cannabis Plant

Investigation into the flavonoid derivatives of Atriplex tatarica shows that it provides anti-bacterial and anti-biofilm potential against Pseudomonas aeruginosa.

P. aeruginosa is a bacterium that causes infections most frequently in immunocompromised individuals who have been hospitalized for long periods of time. A biofilm is a protective shield that some types of bacteria create for themselves in attempt to protect against host immune system defenses. An infection that evades an immune system can become quickly dangerous should bacterial or biofilm grow in the lungs, kidney, or urinary tracts. Incorporating the flavonoids found in A. tatarica into medical regimen could provide an option for augmenting current treatment for antibiotic-resistant infections. The growth of biofilms, or collections of microorganisms that can grow on a wide variety of surfaces, makes the treatment of Pseudomonas aeruginosa in hospitalized patients with antibiotics markedly more difficult. Certain flavonoids with proven anti-bacterial and anti-biofilm provide an alternative route for helping to manage deadly antibiotic-resistant infections.

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Antibacterial and Antibiofilm Activity of Flavonoid and Saponin Derivatives from Atriplex tatarica against Pseudomonas aeruginosa Download

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