High-Fat Diet

Flavonoid-Like Compound, Resveratrol, Treats Non-Alcohol Liver Disease

Resveratrol attenuates high-fat diet-induced non-alcoholic steatohepatitis by maintaining gut barrier integrity and inhibiting gut inflammation through regulation of the endocannabinoid system

In Summary

A recent study has discovered that resveratrol treats high-fat diet-induced non-alcoholic steatohepatitis (NASH) by modulating the endocannabinoid system. Resveratrol is a flavonoid-like compound found in grapes and berries that acts as an antagonist on cannabinoid receptors. Due to its antagonistic effect on the endocannabinoid system the compound has similar anti-inflammatory properties to cannabidiol and reduces inflammation associated with NASH, as well as maintaining gut barrier integrity. Further research should conclude the efficacy of this treatment. 

Highlighted in this study is the possible therapeutic benefits of polyphenols, such as flavonoids, due to their antioxidant and protective properties. Resveratrol is a non-flavonoid polyphenol found in common fruits, but fruits and other common crops already harvested in the United States are full of polyphenols that have therapeutic benefits. Cannabis plants are full of flavonoids that have been featured in recent literature as novel drug therapies but polyphenols found in a myriad of crops are still undervalued in western medicine and warrant further investigation. 

The study is available for review or download here:

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Benjamin Caplan, MDFlavonoid-Like Compound, Resveratrol, Treats Non-Alcohol Liver Disease
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