Non-Cannabis Plant

An Extract from Monkshood Treats Chronic Heart Failure

March 2, 2020 Cardiovascular Effects, Non-Cannabis Plant

Higenamine, a Dual Agonist for β1- and β2-Adrenergic Receptors Identified by Screening a Traditional Chinese Medicine Library

In Summary

A recent Chinese study has found an herbal compound that promises to treat chronic heart failure. Higenamine, an alkaloid found in monkshood, has been found to be a dual agonist for a receptor pathway that has been implicated in the late stages of heart disease. Monkshood has already been utilized in Chinese medicine and the isolation of higenamine is an exciting advancement for the therapeutic benefits this herb provides. Further studies are needed to confirm higenamine’s ability to treat chronic heart failure.

This study brings to light the number of herbal compounds used in eastern medicine that are not yet being utilized in western medicine. In the United States herbs are just now starting to be seriously researched for medicinal properties in a lab setting despite their importance in eastern medicine and home remedies. Extracts of naturally occurring compounds are finally coming to the forefront of medicine as the public looks for natural and sustainable remedies for everyday ailments, treatment-resistant disorders, and even cancer. The potential of these compounds deserves serious consideration in today’s medicine.

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High Flavonoid Content of Dry Birch Leaves Makes for High Antioxidant Potential

February 28, 2020 Anti-inflammatory properties, Antioxidant, Flavonoids, Non-Cannabis Plant

Antioxidant Activity of Dry Birch (Betula Pendula) Leaves Extract

In Summary

Plants with high flavonoid content, including but not limited to cannabis, tend to exhibit vast health benefits, including but not limited to anti-inflammation, anti-oxidant, anti-cancer, and anti-bacterial applications.

The medicinal use of Betula Pendula, or dry birch leaves dates back as far as Ancient Greece. Birch leaf extracts exhibit anticancer, antifungal, diuretic, antimicrobial, antiflammatory properties, and more. In order to determine the antioxidant capabilities of birch leaf extract, researchers determined flavonoid content in leaves and administered extracts to rats and subsequently analyzed the antioxidant potential of the rats’ plasma. The leaves had a total flavonoid content of 42.5 milligrams per gram and short-term application of extract to rats resulted in enhanced antioxidant potential in their plasma. Chronic application was not as effective as short-term application. Overall, the high flavonoid content of dry birch leaves allows for high antioxidant potential, as well as a range of other health benefits.

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Atriplex Tatarica Flavonoids Show Anti-Bacterial and Anti-Biofilm Activity

January 15, 2020 Anti-Bacterial, Antibiotics, Flavonoids, Non-Cannabis Plant

Investigation into the flavonoid derivatives of Atriplex tatarica shows that it provides anti-bacterial and anti-biofilm potential against Pseudomonas aeruginosa.

P. aeruginosa is a bacterium that causes infections most frequently in immunocompromised individuals who have been hospitalized for long periods of time. A biofilm is a protective shield that some types of bacteria create for themselves in attempt to protect against host immune system defenses. An infection that evades an immune system can become quickly dangerous should bacterial or biofilm grow in the lungs, kidney, or urinary tracts. Incorporating the flavonoids found in A. tatarica into medical regimen could provide an option for augmenting current treatment for antibiotic-resistant infections. The growth of biofilms, or collections of microorganisms that can grow on a wide variety of surfaces, makes the treatment of Pseudomonas aeruginosa in hospitalized patients with antibiotics markedly more difficult. Certain flavonoids with proven anti-bacterial and anti-biofilm provide an alternative route for helping to manage deadly antibiotic-resistant infections.

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Antibacterial and Antibiofilm Activity of Flavonoid and Saponin Derivatives from Atriplex tatarica against Pseudomonas aeruginosa Download

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Brazilian Medicinal Plant Shows Important Anti-inflammatory Action

January 14, 2020 Anti-inflammatory properties, Non-Cannabis Plant, Pain

Anti-inflammatory activity of Protium spruceanum is associated to immunomodulation and enzymes inhibition

In Summary:

Protium spruceanum, a plant often used in traditional Brazilian medicine, can reduce inflammation. Investigation into the molecular action of the plant shows that treatment using both leaves and branches can result in the inhibition of ROS, NO, NAG, MMP-9, COX-2, and iNOS, all normal mediators of inflammation. Protium spruceanum is one of many plants containing high phenol/flavonoid, terpenoid, and glycoside content that exhibits notable anti-inflammatory properties.

Related image Protium spruceanum with anti-inflammatory activity

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Anti-inflammatory activity of Protium spruceanum (Benth.) Engler is associated to immunomodulation and enzymes inhibition Download

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Anti-Cancer and DNA Protective Capabilities of a Non-Cannabis Plant

January 9, 2020 Breast Cancer, Extraction, Non-Cannabis Plant

Investigation of chemical profile, biological properties of Lotus corniculatus extracts and their apoptotic-autophagic effects on breast cancer cells

In Summary:

A study of Lotus corniculatus demonstrated that extracts of the plant possess antioxidant, DNA protective, wound healing, and anti-cancer properties. L. corniculatus, known colloquially as bird’s foot trefoil, is a plant commonly used during off-season to manage erosion and prepare feed for livestock. The plant has been used for medicinal purposed to treat IBS and insomnia. Researchers prepared extracts of the plant in water, ethyl acetate and methanol to compare differences between the three solvents. Water extracts exhibited the most significant antioxidative and protective DNA properties, while both ethanol and ethyl acetate extracts induced death in and prevented the migration and proliferation of breast cancer cells.

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Wound-Healing Activity and Phytochemical Screening of Purified Fractions of Crassulaceae Leaves on HCT 116 Cells

January 6, 2020 Non-Cannabis Plant, Topical

A Common Succulent Provides Wound Healing Benefits

In Summary

A recent study has found that Sempervivum tectorum L. (Crassulaceae), a common succulent, has wound healing properties. During testing, it was demonstrated that an extract of the succulent, known to be rich in flavonoids, enhanced cellular proliferation and migration, proving its therapeutic benefit. The authors have suggested that a topical treatment made from the extract would be an efficient delivery method.

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Wound healing activity and phytochemical screening of purified fractions of Sempervivum tectorum L. leaves on HCT 116 Download

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A Flavonol from Sweetscented Marigold Alleviates Pain

December 24, 2019 Analgesic, Arthritis, Cooking, Flavonoids, Future Medicine, Muscle Pain, Non-Cannabis Plant, Pain

Tagetes Lucida as a potential analgesic

In Summary:

Researchers have recently provided evidence that a flavonol extract derived from a common flower has antinociceptive (pain-relieving) properties. Sweet-scented Marigold has been used is frequently used in cooking techniques in South America and has now been found to alleviate pain through serotonin and opioid mechanisms of action. The antinociceptive properties of this flavonol, like those of many other plant-derived compounds, are ripe for testing in a clinical setting to determine their effectiveness in human patients. In this small animal study, it clearly demonstrates promise as a safe alternative to commonly used pain medications.

Dr. Caplan and the #MDTake:

Modern medicine seems to have largely forgotten its roots. Long before pharmaceutical companies were the source of all medication, the earth served as a resource for medications, and apothecaries, pharmacists, and druggists, as they were known, supported the medical industry with formulations and a deep understanding of natural resources. As the greater scientific arena and dominant culture have lost touch with the earth’s natural medicinal resources, our culture has lost a deeply valuable reservoir of opportunity. As the fast-paced life of modernity demands faster results on an ever-greater, mass-production scale, the construction of sprawling cities, which often demands deforestation and destruction of natural resources, may turn out to be a greater threat to human health than most of us have yet to even understand.

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Tagetes Lucida as a potential analgesic Download

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Medicinal Value of Citrus Peels

July 12, 2019 Anti-inflammatory properties, Antioxidant, Citrus, Dermatology / Skin, Extraction, Flavonoids, Neuropathy, Non-Cannabis Plant, Processing, Products, Science, Testing

Citrus peels waste as a source of value-added compounds: extraction and quantification of bioactive polyphenols

Previous analysis of citrus peels has demonstrated high content of biologically active polyphenols, with significant quantities of flavonoids and phenolic acids present. Both these compounds have been associated with antioxidant, anti-inflammatory, antiproliferative, anti-allergic, antiviral, anticarcinogenic, neuroprotective, and antimicrobial properties.

A recent paper points out that citrus peel waste alone makes up nearly 50% of wet fruit mass discarded as waste and proposes extraction of polyphenols to minimize waste. The bioactive substances in peels can be used in dietary supplements, cosmetics, food products, and pharmaceutical products.

Citrus peels contain significant polyphenols, compounds which have health benefits ranging from antioxidant to anticancer. Polyphenols are also found in large quantities in cannabis, undoubtedly contributing to it many of its well-known health benefits.

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Citrus peels waste as a source of value-added compounds- extraction and quantification of bioactive polyphenols Download

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Flavonoid Content and Antioxidant Potential of Fruits, Tubers, and Legumes in the Andean Regions of Ecuador

July 11, 2019 Antioxidant, Extraction, Flavonoids, Non-Cannabis Plant, Science

Chemical composition and Antioxidant Activity of the Main Fruits, Tubers and Legumes Traditionally Consumed in the Andean Regions of Ecuador as a Source of Health-Promoting Compounds

Many fruits grown in the Andean regions of Ecuador have been the center of medical and consumer interests due to their health benefits. Many plants from the region have been used, historically, as both food sources and therapeutic agents. In response to limited studies on the antioxidant capacity and bioactive compounds that make up these food sources, researchers analyzed many commonly consumed fruits, tubers, and legumes. These demonstrated high total flavonoid, phenolic, and anthocyanin content, which can contribute to high antioxidant potential. A range of antioxidant potentials exist, and many fruits possess these high antioxidant potentials.

Note: A high flavonoid content in many food sources grown in the Andean regions of Ecuador contributes to high antioxidant potential in many of these fruits, tubers, and legumes. Many plants, including cannabis, have high flavonoid content that gives them many viable therapeutic applications.

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Between Bitter and Sweet Honey, from Algeria Mediterranean Coast, Different Flavonoid Content Contributes to Distinct Antioxidant Potentials

July 11, 2019 Addiction, Anti-inflammatory properties, Antioxidant, Cannabinoids, Cannabis, Cannabis Education, Cannabis Science, Extraction, Flavonoids, Future Medicine, History, Honey, Non-Cannabis Plant, Processing, Science

Characteristics of the bitter and sweet honey from Algeria Mediterranean coast

Previous research on honey and its historical use in traditional medicine has pointed toward its therapeutic application for the immune system, anemia, and heart function, among other conditions.

Two kinds of honey harvested from the Algeria Mediterranean coast, so-called poly-floral sweet honey and uni-floral bitter honey, have demonstrated their many medicinal uses. In a comparative analysis of the two kinds of honey, bitter honey had higher flavonoid content, lower sucrose content, and higher total polyphenols and tannins levels, giving it an increased antioxidant potential over sweet honey.

Additional Point: Factors including a higher flavonoid content in uni-floral bitter content gives it an improved antioxidant potential over poly-floral sweet honey. This makes for a wide variety of clinical benefits, including treatment of anemia, colon cancer, improved immune function, and more.

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Characteristics of the Bitter and Sweet Honey From Algeria Mediterranean Coast Download

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