All posts tagged: Anti-Inflammatory

Brazilian Medicinal Plant Shows Important Anti-inflammatory Action

Anti-inflammatory activity of Protium spruceanum is associated to immunomodulation and enzymes inhibition

In Summary:

Protium spruceanum, a plant often used in traditional Brazilian medicine, can reduce inflammation. Investigation into the molecular action of the plant shows that treatment using both leaves and branches can result in the inhibition of ROS, NO, NAG, MMP-9, COX-2, and iNOS, all normal mediators of inflammation. Protium spruceanum is one of many plants containing high phenol/flavonoid, terpenoid, and glycoside content that exhibits notable anti-inflammatory properties.

Related image Protium spruceanum with anti-inflammatory activity

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Benjamin Caplan, MDBrazilian Medicinal Plant Shows Important Anti-inflammatory Action
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Spinal Cord Injury and Severe Traumatic Brain Injury Patients Use Cannabis to Manage Symptoms

Cannabis Use in Individuals with Spinal Cord Injury or Moderate to Severe Traumatic Brain Injury in Colorado

In Summary:

Spinal cord injury patients report that medical cannabis helped them alleviate many symptoms of their injury including spasticity, pain, sleep disruptions, stress, and anxiety. Traumatic brain injury patients list their reason for use as reducing stress/anxiety and improving sleep. Both groups of patients reported recreational use prior to and following injury for a variety of reasons.

Dr. Caplan and the #MDTake:

Healing from traumatic injuries is never solely a matter of local tissue changes. The injured tissues, and the experience of being injured create ripple effects which can disrupt multiple other organ systems, and the entire experience of normalcy. A chemical stress response is one of the most common (and often adaptive) responses to an injury, but the burden of stress, adapting to a new illness, and associated loss of normalcy and sleep can be disastrous to the process of healing. As anxiety and sleeplessness snowball into daily problems themselves, a kernel of injury sometimes amplifies to become a life-altering change.

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Benjamin Caplan, MDSpinal Cord Injury and Severe Traumatic Brain Injury Patients Use Cannabis to Manage Symptoms
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Medical Marijuana Offers Benefits Comparable to Prescription Medication, Without the Side Effects

Title: Preferences for Medical Marijuana over Prescription Medications Among Persons Living with Chronic Conditions: Alternative, Complementary, and Tapering Uses

In a survey of 30 patients using medical cannabis for a range of diseases including rheumatoid arthritis, cancer, hepatitis C, PTSD, among others, patients reported an array of benefits they have reaped from cannabis use. Patients successfully used cannabis in several ways: as an alternative to prescription medication, complementarily with prescription medicine, and to gradually replace use of prescription medication.

Benefits described by participants included the effects of cannabis lasting longer than that of opioids, lower risk of addiction, fewer side-effects. Patients also saw their sleep, anxiety, appetite, and adverse reactions improve with the use of medical cannabis. Larger, more controlled studies may suggest cannabis more affirmatively as an alternative or complementary therapy with prescription medications.

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This paper is also stored here:    http://bit.ly/2wqDDdQ     inside the CED Foundation Archive

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Benjamin Caplan, MDMedical Marijuana Offers Benefits Comparable to Prescription Medication, Without the Side Effects
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New Developments of Cannabinoid-Based Drugs

Title: Novel approaches in clinical development of cannabinoid drugs

A pamphlet has recently been published that highlights new approaches in the clinical development of cannabinoid-based therapies. The pamphlet begins with a look into how current cannabinoids affect patients based on gender, stress, physiological variations, and also delves into how cannabis works on the body in general.

A novel therapy that features an oral version of tetrahydrocannabinol (THC) and a synthetic activator of cannabinoid-receptor-1 (CB1) is explored in this piece and frames it to be a promising future therapy. The pharmacological properties of these two novel therapies were optimized during development after various analysis techniques, forming medications that the authors hope to see in future clinical trials. 

Although the authors remain hopeful that their cannabis-based therapies will reach clinical trials soon, trials featuring cannabinoids are difficult to test in a formal setting because of a dire lack of funding. The federal government still lists cannabis as a Schedule I substance, under the Controlled Substances Act, meaning that the federal government does not support the idea that cannabis has any medical use. Considering the legal status of cannabis, only privately-funded studies are able to take place, and unfortunately, that leaves cannabis research in an area of complete bias and prohibitively underfunded. Considering the massive literature supporting a myriad of novel therapeutic benefits, this is a costly reality to the health and well-being of millions.


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Benjamin Caplan, MDNew Developments of Cannabinoid-Based Drugs
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Forbes feature: Solo Sciences

A worthy look at the future of consumer empowerment in cannabis and beyond: Solo Sciences, inc

https://www.forbes.com/sites/mikeadams/2019/07/30/former-cia-profiler-claims-most-packaged-cannabis-products-are-fake/#2ad55a7f66c1

Check out http://solosciences.com for more!

Benjamin Caplan, MDForbes feature: Solo Sciences
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Video: Legalization of Cannabis?

Medical marijuana is legal in 33 states, and recreational marijuana is legal in 11. But on a federal level, the use and possession of marijuana is illegal for any purpose. The illegal status of cannabis prohibits research opportunities and hinders the safety of cannabis sales.

Watch this video for 4 reasons to legalize marijuana on a federal level

Benjamin Caplan, MDVideo: Legalization of Cannabis?
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Video: Do-It-Yourself Cannabis Tinctures

One of the terrific realities of modern Cannabis is that it is possible, and often quite simple, to make effective products at home. With suitable education and access to testing facilities, the soil, nutrients, and plant growth can be supported at home, lab-tested for make-up and potency, as well as safety-checked for potential microscopic contaminants, and ultimately, individualized medicine can be created right at home!

Here is a sample instructional for just one way that cannabis tincture can be made at home. There are countless others and hopefully, many that are yet to be discovered!

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Benjamin Caplan, MDVideo: Do-It-Yourself Cannabis Tinctures
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Video: Cannabinoids and autoimmune diseases: A systematic review

This literature review summarizes the findings on the role of cannabis in treating autoimmune diseases. Cannabis has anti-inflammatory properties when treating rheumatoid arthritis, scleroderma, type 1 diabetes, IBD, neuropathic pain, and fibromyalgia. Below is a video adaptation of “Cannabinoids in Rheumatoid Arthritis.” 

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This paper is also stored here:  http://bit.ly/2Y1paV5       inside the CED Foundation Archive

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Benjamin Caplan, MDVideo: Cannabinoids and autoimmune diseases: A systematic review
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Cannabidiol Treatment for Parkinson’s Disease

Cannabidiol: a hope to treat non‑motor symptoms of Parkinson’s Disease Patients

Cannabidiol (CBD) has recently been postulated as an ideal drug to address the treatment of non-motor symptoms of Parkinson’s Disease (PD) due to its multifaceted mechanism of action. The plethora of effects of CBD includes anti-inflammatory, neuroprotective, anxiolytic, and antipsychotic actions, which improve non-motor symptoms of PD and lift the quality of life for patients coping with the illness. Further research is recommended to garner support for FDA approval.

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This paper is also stored here:    http://bit.ly/2KXTb0Y     inside the CED Foundation Archive

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Benjamin Caplan, MDCannabidiol Treatment for Parkinson’s Disease
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Study Reveals that Flavanoids can act as Allergy Medications

Anti-histaminic Effects of Resveratrol and Silymarin on Human Gingival Fibroblasts

It has recently been revealed that the flavonoids resveratrol and silymarin have an anti-histaminic effect on human gingival fibroblasts (HGF). HGF are cells that compose part of the gum tissue in the oral cavity. Silymarin and resveratrol were already known to have anti-bacterial and anti-inflammatory properties, but a recently published study has now revealed that silymarin alone and a combination of the two flavonoids both provide novel therapeutic approaches for inflammation due to allergies.

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This paper is also stored here:    http://bit.ly/2Ff1lhW   inside the CED Foundation Archive

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Benjamin Caplan, MDStudy Reveals that Flavanoids can act as Allergy Medications
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