CB1-Receptor Archives - CED Foundation

The Therapeutic Potential of Indenopyrazoles

January 10, 2020 Anti-inflammatory properties, Cannabinoids, CB1, CB2

An overview of the synthetic and medicinal perspectives of indenopyrazoles

In Summary:

Indenopyrazoles, molecules crucial to many biological signaling pathways, have been found to bind to cannabinoid receptors and seem to exhibit therapeutic properties in a variety of conditions. A review of studies on the molecule describes previously documented antimycobacterial, antipsychotic, anti-tumor, and anti-microbial properties, among others. The molecule has demonstrated moderate affinity for both cannabinoid-1 and cannabinoid-2 receptors, suggesting possible additional anti-inflammatory and anti-neurodegenerative capabilities related to the interactions with these receptors. Further research may uncover additional therapeutic applications and shed light on additional benefits of cannabinoid receptors.

Graphical abstract of actions of indenopyrazoles

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An overview on the synthetic and medicinal perspectives of indenopyrazolesDownload

This paper is also stored here: http://bit.ly/2ZBdDJc inside the CED Foundation Archive

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The Endocannabinoid System May Play a Role in Autism Spectrum Disorders

July 12, 2019 Animal Model, Autism, Behavior change, Cannabinoids, Cannabis, Cannabis Science, CB1, Future Medicine, Science, Stigma

Title: CB1 receptor antagonism in capuchin monkeys alters social interaction and aversive memory extinction

A recent study has revealed that the dysregulation of the endocannabinoid system may play a role in autism spectrum disorders (ASD). Using non-human primates, researchers were able to mimic some of the social impairment seen in autism models by antagonizing cannabinoid 1 receptors with synthetic cannabinoids. Future research may continue to show links between ASD and the endocannabinoid system, suggesting that cannabinoids may be used to treat the social impairments characteristic in ASD.

This research highlights how the endocannabinoid system may provide novel targets for developing therapies for what have seemed, previously, to be treatment-resistant disorders. Autism is still not well-understood and has many false beliefs associated with it. By studying the possible role of the endocannabinoid systems in ASD, researchers may be able to shed light on the mechanism(s) underlining the disorders and develop targeted treatments that allow patients a degree of greater control over the symptoms.

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CB1-receptor-antagonism-in-capuchin-monkeys-alters-social-interaction-and-aversive-memory-extinction Download

This paper is also stored here: http://bit.ly/2Ju4dds inside the CED Foundation Archive

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Countering the Modern Metabolic Disease Rampage With Ancestral Endocannabinoid System Alignment

June 11, 2019 Cannabinoids, Cannabis, Cannabis News, Cannabis Science, CB1, Diabetes, Future Medicine, History, News, Science, Social Justice

Cannabinoid receptors, located throughout the body, are involved in a variety of physiological processes (including appetite, mood, etc.). A 2019 study shows that blocking CB1Rs (cannabinoid receptors that conserve energy) is an effective way to manage metabolic disorders, such as obesity and Type-2 Diabetes.

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Countering the Modern Metabolic Disease Rampage With Ancestral Endocannabinoid System Alignment Download

This paper is also stored here: http://bit.ly/31rATuL inside the CED Foundation Archive

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Cannabinoid receptors as therapeutic targets for autoimmune diseases: where do we stand?

June 7, 2019 Anti-inflammatory properties, Arthritis, Autoimmunity, Cannabinoids, Cannabis, Cannabis Education, Cannabis Science, CB1, CB2, CBD, Diabetes, Future Medicine, Multiple Sclerosis

Because of the associated anti-inflammatory action, modulation of CB1R & CB2R is helpful to treat autoimmune diseases, including Multiple Sclerosis, Type-1 Diabetes Mellitus, and Rheumatoid Arthritis The full list is truly very much longer, as every illness necessarily involves the immune system and cellular communication.

The following review, written by Elaine D. Gonc ̧alves

Cannabinoids for the treatment of rheumatic diseases — where do we stand?
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The following review, written by Daphna Katz-Talmor: (yes, same name, unfortunately!)

Cannabinoids for the treatment of rheumatic diseases — where do we stand?Download