Neuroprotective effect of catechins derivatives isolated from Anhua dark tea on NMDA-induced excitotoxicity in SH-SY5Y cells
In Summary
Researchers have found that catechins and flavonoids found in Anhua tea provide neuroprotective effects against NDMA-induced excitotoxicity. NDMA receptors are part of the glutaminergic system; glutamate is the most abundant excitatory neurotransmitter in the human nervous system. During dysregulation of the glutaminergic system, an excess of glutamate can cause excitotoxicity which can lead to brain injury and cell apoptosis. The compiled data suggests that at least one of the naturally occurring compounds in Anhua tea is effective at protecting against NMDA-induced brain injury and cell apoptosis when given as a dietary supplement.
This research may prove beneficial for developing preventative therapies for Alzheimer’s disease, depression, stroke, epilepsy, and schizophrenia. Anhua tea has been used in eastern medicine for centuries and like other herbal compounds in eastern medicine, has recently been featured in modern research. Considering the myriad of potential therapies that have been suggested due to the recently found medical benefits of herbal medicine, westerners should begin taking advantage of flavonoids and the like compounds that have been booming in Chinese medicine. Flavonoids and terpenes are two categories of naturally occurring compounds that have, so far, shown promise as novel therapies for treatment-resistant ailments, yet are still incredibly under-researched. Explore more of our blog to find out what other medical benefits can be provided by flavonoids and terpenes.
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