All posts tagged: Sativex

Is Sativex absorbed in the mouth or gut? To eat or not to eat beforehand?

Article Title: A meta-opinion: cannabinoids delivered to oral mucosa by a spray for systemic absorption are rather ingested into gastro-intestinal tract: the influences of fed/fasting states.

Sativex® spray is made of a 1:1 ratio of THC and CBD. It is marketed for use in the treatment of spasticity in patients with Multiple Sclerosis and is absorbed into the bloodstream through the oral mucosa. This absorption has the benefit of rapid absorption, as it avoids the slow process of digestion which is the typical path of absorption for edibles. This meta-opinion (expert opinion) review argues that Sativex is actually washed down by our saliva and digested through our gastrointestinal tract very much like edibles, and NOT merely absorbed in the mouth via oral mucosa, as the producers suggest. The authors reviewed several research studies which have found that the concentrations of THC and CBD in the body, following administration of Sativex differed if a patient had a meal or not beforehand. This would suggest that Sativex is indeed absorbed in the gastrointestinal tract, rather than merely through the oral mucosa.

How this matters to consumers:

Toward a goal of reproducible dosing and effects, consumers would do well to understand the effects of various methods of absorption. Specifically, it is helpful to know that the effect of Sativex may be delayed if it follows a meal.

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This paper is also stored here:     inside the CED Foundation Archive

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Benjamin Caplan, MDIs Sativex absorbed in the mouth or gut? To eat or not to eat beforehand?
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Sativex Reduces MS-Related Spasticity

Delta-9-Tetrahydrocannabidiol Oromucosal Spray (Sativex): A Review in Multiple Sclerosis-Related Spasticity

A debilitating symptom of multiple sclerosis (MS) is spasticity, the stiffness and involuntary spasms of muscles, often occurring in the legs. In a randomized study involving MS patients who have not experienced relief with any current anti-spasticity medication, Sativex, a THC/CBD oro-mucosal spray was administered. Patients receiving THC/CBD experienced significantly more spasticity relief than the placebo group. Sativex may hold substantial treatment potential for MS patients, as side effects are minimized, the spray allows for an adjustable dosage, and there is low potential for abuse.

While this pharmaceutical is proving to be effective, in related data, we also see a distinct advantage of non-pharmaceutical options, including cost, availability, and efficacy, although drastically higher variability and limited consistency in product.

Benjamin Caplan, MDSativex Reduces MS-Related Spasticity
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