The bioflavonoids as protein tyrosine phosphatase 1B inhibitors from Selaginella uncinata and their antihyperglycemic action
Researchers have recently revealed the antihyperglycemic effects of flavonoids extracted from peacock moss. Nine biflavonoids were extracted from peacock moss (Selaginella uncinata) and examined for their effect on protein tyrosine phosphatase 1B, which is a regulatory protein of the insulin pathway, and were all found to have an inhibitory effect. Each of the flavonoids was found to be an allosteric modulator with a highly efficient binding mechanism. The antihyperglycemic effects of these flavonoids may lead to novel treatments for high blood sugar and may lend itself to regulating symptoms of diabetes.
Highlighted in this study is the possible therapeutic benefits of chemicals produced by cannabis other than cannabinoids, such as flavonoids, due to their antioxidant and protective properties. Flavonoids and terpenes are often found in common fruits and fruits and other common crops, like moss, already harvested in the United States are full of polyphenols that have many therapeutic benefits. Cannabis plants are full of flavonoids and terpenes that have been featured in recent literature as novel drug therapies but polyphenols can also be found in a myriad of crops that are still undervalued in western medicine and warrant further investigation.
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