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Recently Identified Mechanism of Chronic Stress-Induced Pain

June 22, 2019 Addiction, Cannabinoids, Cannabis, Cannabis Science, CB1, CB2, CBD, Cognition, Cortisol, Depression, Future Medicine, History, Mental Health, Pain, Science, Stress, THC

Chronic Stress Is Associated with Pain Precipitation and Elevation in DeltaFosb Expression

Researchers have identified Delta-FosB, an osteosarcoma viral oncogene, as a useful molecular marker of sustained pain. The expression of Delta-FosB is significantly elevated by stress-induced pain, exposing its role in the adaptability of nerves. This study supports theories that Delta-FosB plays an important role in drug addiction, depression, and stress adaptation. The interaction between stress, depression, and pain is something that is not yet well-understood. But, as we learn more about cannabis-based medicine, many of the age-old questions about pain have become much clearer.

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Chronic Stress Is Associated with Pain Precipitation and Elevation in DeltaFosb Expression Download

This paper is also stored here: http://bit.ly/31A7Y86 inside the CED Foundation Archive

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Profile of Dr Caplan, Dr Grinspoon, CED Clinic, and modern Medical Cannabis in Alcoholism & Drug Abuse Weekly

June 21, 2019 Addiction, Alcohol, Anxiety, Behavior change, Cannabis, Cannabis Education, Cannabis News, CED Clinic, CED In The News, Dispensaries, Dr Caplan, Dr Grinspoon, Future Medicine, Illicit Drug Use, Law, Legislation, Massachusetts, Politics, Social Equity, Social Justice, THC

The esteemed medical periodical, Alcoholism & Drug Abuse Weekly, takes a closer look at modern medical cannabis with Dr Grinspoon and I. Our discussion brings an insider’s look at how the system operates, from clinic to dispensary, the dynamic changes we’ve already seen and highlights some of the changes to come. Included are The Role of Medicine, The Ethics of doctors in business, The Patient Experience, Physician’s Support, Growing the Plant, and a sit-down with a local dispensary.

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ADAW-June-24-2019 Download

This paper is also stored here: http://bit.ly/2Lc2H0R inside the CED Foundation Archive

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Cannabinoid Receptors Working with Opioid Receptors

June 21, 2019 Addiction, Adolescents, Anxiety, Behavior change, Cannabinoids, Cannabis, Cannabis Science, CB1, CB2, CBD, Cognition, Future Medicine, Memory, Neuropathy, Opiates, Science

The locus coeruleus is a spot in the human brainstem that is integral to our responses to stress, panic, wakefulness, and sleep-wake transitions. Both the cannabinoid receptors and opioid receptors in the locus coeruleus have a synergistic relationship that, once the medical system begins to incorporate more education about cannabinoids, just might change how physicians prescribe pain medication. The interactions of the two receptor types provide a mechanism that could easily and conveniently improve pain control, provide treatments for addiction, and will likely aid those experiencing symptoms of withdrawal. Research focusing on the treatment of opioid addiction with cannabis is ongoing… but hindered by the legal status of cannabis.

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Characterization of cannabinoid-1 receptors in the locus coeruleus relationship with mu-opioid receptors Download

This paper is also stored here: http://bit.ly/2MMeYeK inside the CED Foundation Archive

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Adolescent Executive Dysfunction in Daily Life: Relationships to Risks, Brain Structure and Substance Use

June 19, 2019 Addiction, Adolescents, Adverse Effects, Anxiety, Behavior change, Bipolar Disorder, Cannabinoids, Cannabis, Cannabis Education, Cannabis Science, CBD, Cognition, Depression, DSM-5, Future Medicine, Memory, Mood, Pediatrics, Science, Stigma, Stress

Researchers assessed 817 youth (aged 12 to 21) who previously participated in the National Consortium on Alcohol and Neurodevelopment in Adolescence study. They found that 123 subjects (15.2%) had used cannabis in the past year, and that cannabis use impaired inhibitory control, emotional control, and task planning.

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Adolescent Executive Dysfunction in Daily Life- Relationships to Risks, Brain Structure and Substance Use Download

This paper is also stored here: http://bit.ly/2L0aMWa inside the CED Foundation Archive

A Call for Physicians to Embrace Medicinal Cannabis as a Virtuoso of Prudence

June 17, 2019 Addiction, Adverse Effects, Anxiety, Behavior change, Cannabinoids, Cannabis, Cannabis Education, Cognition, Future Medicine, History, Regulation, Social Justice

The Prescription of Medicinal Cannabis and the Virtue of Prudence: Without Phobia(S) Nor Philia(S)

A passionate physician shared his opinion on prescribing patients medicinal cannabis, promoting its use in accordance with the virtue of prudence. The piece implores physicians to identify the medicinal benefits of cannabis and embrace its side effects without fear. Medicinal cannabis has its place among prescriptions with “respect for leges artis” as long as the decision to recommend cannabis is the result of an ethical-clinically based decision.

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The Prescription of Medicinal Cannabis and the Virtue of Prudence-Without Phobia(a) Nor Philia(a)Download

This paper is also stored here: http://bit.ly/2Ff3mLc inside the CED Foundation Archive

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