Dramatic response to Laetrile and cannabidiol (CBD) oil in a patient with metastatic low grade serous ovarian carcinoma
A recent case study has examined a patient’s response to the consumption of cannabidiol (CBD) as a treatment for a rare type of ovarian cancer. Rather than participate in chemotherapy, which has been shown to only be effective in 5% of patients with low grade serous ovarian carcinoma, an 81-year-old decided to take a combination of amygdalin and CBD. Although CBD has only been shown to have effective anti-cancer properties in murine models the featured patient reported a significant decrease in tumor size, revealing that CBD may, in fact, be an effective treatment for patients looking into alternative care methods.
Although proven ineffective, the use of amygdalin highlights alternative therapies derived from naturally occurring chemicals found in common plants. Flavonoids and terpenes are chemical components of cannabis plants, also found in a variety of fruits and vegetables, that are just now being investigated for their therapeutic benefits. The results of those inquiries may prove useful for similar patients suffering from illnesses that are resistant to the usual treatments.
State laws in Florida allow card-holding seniors to use cannabis, but federally-subsidized senior homes must go against status-quo to allow this. The benefits are not being denied, but if they want to participate in Medicare then cannabis use comes with great risk. http://bit.ly/2LmKJZg
Benjamin Caplan, MDSeniors, in assisted living, and Cannabis
A 2019 literature review summarizes the findings on cannabis use for patients with multiple sclerosis. Cannabis has been shown to aid a number of symptoms associated with multiple sclerosis, including chronic pain, spasticity, and problems with sleep. To learn more, check out our video adaptation below:
In a crossover trial of 39 patients with Alzheimer’s disease, treatment with nabilone (a synthetic THC analog) was associated with significant improvement in agitation and, remarkably, cognition. Further studies should examine the effects of both THC and CBD in patients with Alzheimer’s disease because anxiety is common in dementia and may exacerbate agitation.
Oxaliplatin is the most commonly used drug to treat colorectal cancer (CRC), but patients often develop resistance to it. So, researchers conducted a study to determine the effect of CBD in overcoming oxaliplatin resistance in CRC cells. They found that elevated NOS3 phosphorylation is an essential part of the development of oxaliplatin resistance, and CBD successfully decreased NOS3 phosphorylation. This effect resulted in cells overcoming oxaliplatin resistance, which suggests that CBD could be a new strategy to treat colorectal cancer.
In the US, the largest increase in cannabis use was seen in the older adult population. And with medical cannabis reducing pain associated with work, researchers wonder if cannabis could postpone retirement plans and enhance the US labor supply. https://www.greenentrepreneur.com/article/335478
Benjamin Caplan, MDThere’s Growing Evidence Cannabis Helps Older Adults Keep Their Jobs for Years Longer
Effects of Drug Abuse, Smoking and Alcohol on Donor Hearts and Lungs
A review article that discusses how drug use can affect donor organs has revealed that receiving organs, such as a heart or lungs, from a donor who has used cannabis does not add risk to the procedure. A careful assessment of any donor organ should still be conducted, but having a history of cannabis use does not prevent someone from safely donating.
A recently published study looking to expose the functional status of older drug users has found that most of their cognitive abilities are equal to their peers who have never smoked cocaine, except for a marginally lower verbal comprehension. Similar studies should continue in order to determine how chronic drug users will affect or challenge public health systems in the future.