Arthritis

Efficacy of Cannabinoids in a Pre-Clinical Drug-Screening Platform for Alzheimer’s Disease

Researchers find 9 cannabinoids that might protect the brain against toxicities associated with aging. These non-intoxicating cannabinoids are potential drug candidates for Alzheimer’s Disease, and they might also be options for other neurodegenerative diseases, too

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This paper is also stored here:     http://bit.ly/2L9GccX    inside the CED Foundation Archive

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Benjamin Caplan, MDEfficacy of Cannabinoids in a Pre-Clinical Drug-Screening Platform for Alzheimer’s Disease
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Researchers Look to CBD and THC for the Treatment of Chronic Pain

Efficacy and safety of cannabidiol followed by an open-label add-on of tetrahydrocannabinol for the treatment of chronic pain in patients with rheumatoid arthritis or ankylosing spondylitis: protocol for a multicentre, randomized, placebo-controlled study

Current researchers have proposed a study protocol that would expose any possible benefits of cannabidiol (CBD) and tetrahydrocannabinol (THC) for the treatment of chronic pain in patients suffering from rheumatoid arthritis (RA) and ankylosing spondylitis (AS). This new study hopes to identify how medical cannabis affects pain and cognitive function in RA and AS and provide evidence that cannabis-based pain medication is an alternative to opioids with fewer risks.

This paper is also stored here:    http://bit.ly/2Fb08s5     inside the CED Foundation Archive

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Benjamin Caplan, MDResearchers Look to CBD and THC for the Treatment of Chronic Pain
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The Education of Dispensary Staff is Varied and Lacks Regulation

Training and Practices of Cannabis Dispensary Staff

How much medical training does your local budtender possess? An online survey sent to medical marijuana dispensary staff reported only 55% of staffers had any formal training for their position, with 20% reporting some background in medical/scientific training. The analysis reported that many among the dispensary staff are recommending cannabis choices that are consistent with current evidence, but some are recommending strains that are either ineffective or exacerbate a patient’s condition. The findings of this study stress the importance of consistent and well-regulated training of dispensary staff.

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This paper is also stored here:    http://bit.ly/2FfJNSC     inside the CED Foundation Archive

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Benjamin Caplan, MDThe Education of Dispensary Staff is Varied and Lacks Regulation
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A 2018 study finds that cannabis can alleviate symptoms of medications used for chronic pain as well as serve as an alternative treatment for seizures, pain, and inflammation.

Benjamin Caplan, MDA 2018 study finds that cannabis can alleviate symptoms of medications used for chronic pain as well as serve as an alternative treatment for seizures, pain, and inflammation.
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Synthetic Cannabinoids Provide Evidence for Targeting Cannabinoid Receptors in the Treatment of Autoimmune Diseases

Pharmaceutical Cannabis Derivatives Help Discover their Receptors and Functions for Autoimmune Illnesses

A recent study conducted by Michigan State University exposed the potential for cannabinoid receptor 2 (CB2) to target the treatment of inflammatory conditions. Elevated levels of plasmacytoid dendritic cells (pCD, a type of cell in the immune system) contribute to chronic inflammation in autoimmune diseases, such as Rheumatoid Arthritis. Researchers found that synthetic CB2 agonists reported comparable benefits to THC, but minimized the cerebral effects as the psychotropic activity is mediated by cannabinoid receptor 1 (CB1). This evidence demonstrates the potential benefits of CB2-targeted treatment for inflammatory conditions. Unfortunately, there are serious concerns about the misuse of some synthetic cannabinoids, so there is still a missing bridge, in products and public education, between these research products and potential therapeutic pharmaceuticals, down the road.

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Benjamin Caplan, MDSynthetic Cannabinoids Provide Evidence for Targeting Cannabinoid Receptors in the Treatment of Autoimmune Diseases
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Medical Marijuana Confers Benefits Comparable to Prescription Medication, Without the Side Effects

Preferences for Medical Marijuana over Prescription Medications Among Persons Living with Chronic Conditions: Alternative, Complementary, and Tapering Uses

In a survey of 30 patients using medical cannabis for a range of illnesses, including Rheumatoid Arthritis, cancer, Hepatitis C, PTSD, and more, patients reported an array of benefits from their cannabis use. Patients successfully used cannabis as an alternative to prescription medication, as a complementary agent with traditional prescription medicines, and to gradually help halt the use of some prescription medications. Benefits described by participants included the effects of cannabis lasting longer than that of opioids, lower risk of addiction, fewer side-effects. Patients also saw their sleep, anxiety, appetite, and adverse reactions improve with the use of medical cannabis. Larger, more controlled studies may suggest cannabis more affirmatively as an alternative or complementary therapy with prescription medications.

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This paper is also stored here:   http://bit.ly/2wqDDdQ      inside the CED Foundation Archive


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Benjamin Caplan, MDMedical Marijuana Confers Benefits Comparable to Prescription Medication, Without the Side Effects
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Some, But Not Enough Data on Cannabis for Chronic Pain

Overlaps in pharmacology for the treatment of chronic pain and mental health disorders

Select small trials have demonstrated cannabis to be more effective than other analgesics to treat chronic pain associated with certain conditions. However, the existing research lacks large-scale, controlled experiments relating medical cannabis use to pain management. Additionally, negative effects are documented with respect to cannabis use among adolescents and those suffering from compromised mental health. There is a need for further research on the topic.

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This paper is also stored here: http://bit.ly/2wtvpRY inside the CED Foundation Archive

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Benjamin Caplan, MDSome, But Not Enough Data on Cannabis for Chronic Pain
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Cannabinoid receptors as therapeutic targets for autoimmune diseases: where do we stand?

Because of the associated anti-inflammatory action, modulation of CB1R & CB2R is helpful to treat autoimmune diseases, including Multiple Sclerosis, Type-1 Diabetes Mellitus, and Rheumatoid Arthritis The full list is truly very much longer, as every illness necessarily involves the immune system and cellular communication.

The following review, written by Elaine D. Gonc ̧alves

The following review, written by Daphna Katz-Talmor: (yes, same name, unfortunately!)

Benjamin Caplan, MDCannabinoid receptors as therapeutic targets for autoimmune diseases: where do we stand?
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A selective CB2 agonist protects against the inflammatory response and joint destruction in collagen-induced arthritis mice

In a study of 40 mice, scientists find that the CB2-selective agonist significantly reduced the severity of arthritis and markedly reduced bone erosion. These data clearly indicate that the CB2-selective agonist may be considered a novel treatment for rheumatoid arthritis.

Benjamin Caplan, MDA selective CB2 agonist protects against the inflammatory response and joint destruction in collagen-induced arthritis mice
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