Cancer

Prospective analysis of safety and efficacy of medical cannabis in a large, unselected population of patients with cancer

In a study of 2,970 cancer patients, researchers determined that cannabis as a palliative treatment seems to be well tolerated, effective and a safe option to help patients cope with cancer-related symptoms.

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Benjamin Caplan, MDProspective analysis of safety and efficacy of medical cannabis in a large, unselected population of patients with cancer
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Tetrahydrocannabinol and cannabidiol as potential curative agents for cancer. A critical examination of the preclinical literature.

According to multiple mouse-models, THC administered directly into cancerous tumors produces a reduction in tumor sizes.

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Benjamin Caplan, MDTetrahydrocannabinol and cannabidiol as potential curative agents for cancer. A critical examination of the preclinical literature.
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CBD Overcomes Resistance to current treatment of Human Colorectal Cancer Cells

Oxaliplatin is the most commonly used drug to treat colorectal cancer (CRC), but patients often develop resistance to it. So, researchers conducted a study to determine the effect of CBD in overcoming oxaliplatin resistance in CRC cells. They found that elevated NOS3 phosphorylation is an essential part of the development of oxaliplatin resistance, and CBD successfully decreased NOS3 phosphorylation. This effect resulted in cells overcoming oxaliplatin resistance, which suggests that CBD could be a new strategy to treat colorectal cancer. 

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Benjamin Caplan, MDCBD Overcomes Resistance to current treatment of Human Colorectal Cancer Cells
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Dronabinol: antileukemic activity in acute lymphoblastic and myeloid leukemia with lymphoid differentiation patterns

Study provides rigorous data to support clinical evaluation of THC as a low-toxic therapy option in acute leukemia patients. In related work, full-spectrum, natural derivatives of cannabis may work more effectively than their pharmaceutical counterparts.

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Benjamin Caplan, MDDronabinol: antileukemic activity in acute lymphoblastic and myeloid leukemia with lymphoid differentiation patterns
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Recent Study Finds that Astragalin Prevents Tumor Growth

A Kaempferol-3-O-β-D-glucoside, Intervention Effect of Astragalin on Estradiol Metabolism

A recent study found that a flavonoid known as astragalin possesses a strong anti-tumor effect. High levels of a metabolite formed from the hormone estradiol have been found in tumor tissues leading researchers to search for an inhibitor to prevent estradiol from forming the metabolite. This study has found that astragalin, which is a naturally occurring substance found in a variety of plants and wine, has an effective antitumor mechanism that inhibits the formation of the metabolite.

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Benjamin Caplan, MDRecent Study Finds that Astragalin Prevents Tumor Growth
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Compounds in Citrus Peels Functioning as Preventive Agents for Prostate Cancer

Effect of citrus peel extracts on the cellular quiescence of prostate cancer cells

A recent study has revealed that citrus peel extracts (CPE) have the potential to prevent prostate cancer from recurring in post-therapy cancer patients. A component of CPE, flavonoids, have previously been found to have anticancer effects, but appear to lack the correct structure to prevent tumors in patients with prostate cancer. This specific study found that the citric acid present in CPE was the contributing factor to its anticancer effects but mentioned that flavonoids should continue to be researched for chemopreventive benefits.

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Benjamin Caplan, MDCompounds in Citrus Peels Functioning as Preventive Agents for Prostate Cancer
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Video: Medical Marijuana: What Physicians Need to Know

A video adaptation of “Medical Marijuana: What Physicians Need to Know”

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Benjamin Caplan, MDVideo: Medical Marijuana: What Physicians Need to Know
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Cannabis in Cancer Symptom Management

A fascinating session titled “Is There a role for Cannabis in Cancer Symptom Management?” was held yesterday at the 2019 American Cancer Society Annual Meeting.

Bottom line: only once cannabis is legal on a federal level will there be sufficient research about the risks and benefits of cannabis use in patients with cancer. http://bit.ly/2Kq2ruD

Benjamin Caplan, MDCannabis in Cancer Symptom Management
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CBD May Have Potential for Hepatocellular Carcinoma Treatment

Additional research may show potential for CBD as a therapeutic agent for hepatocellular carcinoma

Cannabinoid (CBD) may be an effective treatment for hepatocellular carcinoma (HCC). Cannabinoid receptor 2 (CB2 receptor) has demonstrated anti-tumor behavior in other tumor types. In a new study, HCC cells treated with MDA19, a molecule that binds to the CB2 receptor, grew more slowly than untreated cells. With CBD also binding to the CB2 receptor, there may be precedent for research on the potential of CBD as a treatment for HCC.  

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Benjamin Caplan, MDCBD May Have Potential for Hepatocellular Carcinoma Treatment
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