Cannabinoid 1 Receptor

Cannabinoids have Opioid-Sparing Effects on Morphine Analgesia

Opioid-Sparing Effects of Cannabinoids on Morphine Analgesia- Participation of CB1 and CB2 Receptors

In Summary

Researchers have recently provided evidence that synthetic cannabinoids are able to work synergistically with morphine to provide maximum pain relief while limiting opioid doses. In an effort to control the current opioid epidemic researchers have been looking into the possible benefits of cannabinoids due to the interaction of the opioid and endocannabinoid systems. The results of this study showed that various synthetic cannabinoids (WIN and GP1a) were able to work synergistically with morphine in two separate pain models to maximize analgesic effects. Further evidence is still needed to validate these claims before patient use but this paper provides further evidence that medical cannabis may help put an end to the opioid crisis. 

Highlighted in this paper is the lingering uncertainty of exact mechanisms within the endocannabinoid system. The authors of this article are left without definite answers as to whether or not the analgesic effect is mediated completely through cannabinoid receptor 1 (CB1) or if cannabinoid receptor 2 (CB2) is also involved. Research into cannabinoids is slow within the United States as there are currently only privately funded studies which is severely hindering the medical community from taking full advantage of all it has to offer. The better a system is understood the more definite answers can be found. Critics may never support the rescheduling of cannabis but without moving cannabis to Schedule II or III it remains impossible to back even their claims. 

The study is available for review or download here:

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Benjamin Caplan, MDCannabinoids have Opioid-Sparing Effects on Morphine Analgesia
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The Effects of Cannabinoid 1 Receptor on Memory

A Meta-Analysis and Systematic Review Across Species

In Summary

A recent review has exposed the contrasting information found in human and mouse model studies that study cannabis-based medicines. Acute THC use impairs non-spatial memory in humans and monkeys but not in rodents. Previous research has shown that chronic cannabis use is correlated with lower cognitive function but a mechanism of action for the decline in cognitive function has yet to be identified, and several studies have pointed that the decline is short-lived, perhaps caused by acute intoxication. This study provides evidence for cannabis-based clinical trials due to THC’s species-specific effects on memory. More information is needed to examine the full effect of cannabis on human memory as animal models have now been proven to be inaccurate.


brain and cannabis leaf

View this review (yellow link) or download:

This paper is also stored HERE inside the CED Foundation Archive  

To explore related information, click the keywords below:

Benjamin Caplan, MDThe Effects of Cannabinoid 1 Receptor on Memory
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