CB2

Cannabinoids have Opioid-Sparing Effects on Morphine Analgesia

Opioid-Sparing Effects of Cannabinoids on Morphine Analgesia- Participation of CB1 and CB2 Receptors

Researchers have recently provided evidence that synthetic cannabinoids are able to work synergistically with morphine to provide maximum pain relief while limiting opioid doses.

In an effort to control the current opioid epidemic researchers have been looking into the possible benefits of cannabinoids due to the interaction of the opioid and endocannabinoid systems. The results of this study showed that various synthetic cannabinoids (WIN and GP1a) were able to work synergistically with morphine in two separate pain models to maximize analgesic effects. Further evidence is still needed to validate these claims before patient use, but this paper provides further evidence that medical cannabis may help put an end to the opioid crisis. 

Highlighted in this paper is the lingering uncertainty of exact mechanisms within the endocannabinoid system. The authors of this article are left without definite answers as to whether or not the analgesic effect is mediated completely through cannabinoid receptor 1 (CB1) or if cannabinoid receptor 2 (CB2) is also involved. Research into cannabinoids is slow within the United States, as there are currently only privately funded studies. This severely limits the medical community from a full understanding. The better a system is understood, the more concrete answers can be found. Critics may never support the rescheduling of cannabis but without moving cannabis to a Schedule II or III, it remains impossible to back even their claims. 

View this review (yellow link) or download:

This paper is also stored here:    http://bit.ly/2Xh5PQl     inside the CED Foundation Archive


To explore related information, click the keywords below:

Benjamin Caplan, MDCannabinoids have Opioid-Sparing Effects on Morphine Analgesia
read more

Video: Cannabinoid Delivery Systems for Pain and Inflammation Treatment

A 2018 literature review summarizes the various ways patients can consume cannabis (orally, topically, etc.) and the pain reductions associated with each method. The review focuses on the treatment of multiple sclerosis, cancer, anorexia, arthritis, and other painful disorders.

View this review (yellow link) or download:

This paper is also stored here:    http://bit.ly/2TSZ2Wr     inside the CED Foundation Archive

Benjamin Caplan, MDVideo: Cannabinoid Delivery Systems for Pain and Inflammation Treatment
read more

Patients are Unclear on Cannabis Dosing

Dr. Ernest found that 82% of her epileptic patients found cannabis treatment helpful, but she also found that many of them were unaware of the doses they were taking or the levels of THC and CBD. Doctors and patients alike need to learn about dosing to maximize their health benefits http://bit.ly/2J29kkB

To explore related information, click the keywords below:

Benjamin Caplan, MDPatients are Unclear on Cannabis Dosing
read more

Cannabidiol Treatment for Parkinson’s Disease

Cannabidiol: a hope to treat non‑motor symptoms of Parkinson’s Disease Patients

Cannabidiol (CBD) has recently been postulated as an ideal drug to address the treatment of non-motor symptoms of Parkinson’s Disease (PD) due to its multifaceted mechanism of action. The plethora of effects of CBD includes anti-inflammatory, neuroprotective, anxiolytic, and antipsychotic actions, which improve non-motor symptoms of PD and lift the quality of life for patients coping with the illness. Further research is recommended to garner support for FDA approval.

View this review (yellow link) or download:

This paper is also stored here:    http://bit.ly/2KXTb0Y     inside the CED Foundation Archive

To explore related information, click the keywords below:

Benjamin Caplan, MDCannabidiol Treatment for Parkinson’s Disease
read more

Development of Cannabis-Based Treatment for Bipolar Disorder

Bipolar disorder and the endocannabinoid system

A recently published article serves as a call for research to be conducted to discover how cannabis could impact the management of bipolar disorder (BD). Presented in the article is a full review of the advantages and disadvantages of cannabis-based medicine in the treatment of BD and provides insight into possible mechanisms might affect the pathophysiology of the disorder. The insights listed within the article provide the rationale for examining the endocannabinoid system, specifically the cannabinoid receptor 2, with the hopes of finding therapeutic targets for mood control associated with BD.  

View this review (yellow link) or download:

This paper is also stored here:   http://bit.ly/2FfJXK6      inside the CED Foundation Archive

To explore related information, click the keywords below:

Benjamin Caplan, MDDevelopment of Cannabis-Based Treatment for Bipolar Disorder
read more

The Cannabinoid System is a Promising Source of Targets for Treating Pain

A Budding Source of Targets for Treating Inflammatory and Neuropathic Pain ECS

The cannabinoid system provides momentum to develop cannabinoid-based medications to treat inflammatory and neuropathic pain as researchers continue to find promising therapeutic targets. These new targets may lead to the formation of novel pain-relief medications that may serve well to alleviate pain for those suffering from cancer, multiple sclerosis, and fibromyalgia. Cannabis-based pain medicine is also being researched for opioid-sparing effects and effectiveness in reducing the necessary dose of opioids.

View this review (yellow link) or download:

This paper is also stored here:  http://bit.ly/2FfLorA        inside the CED Foundation Archive

To explore related information, click the keywords below:


Benjamin Caplan, MDThe Cannabinoid System is a Promising Source of Targets for Treating Pain
read more

Video: The Endocannabinoid System’s Intriguing Role in Gut Health

A 2018 literature review summarizes the findings on cannabis and gut health. The endocannabinoid system plays a key role in gut motility, obesity, and inflammatory bowel disease (IBD). Targeting the endocannabinoid system with CBD oil or other cannabinoids seems to reduce colonic inflammation and relieve stress, at a microscopic level, inside the gastrointestinal tract. Watch our video adaptation of the effects of cannabis on IBD:

View this review (yellow link) or download:

This paper is also stored here:    http://bit.ly/2IQCNy1     inside the CED Foundation Archive

To explore related information, click the keywords below:

Benjamin Caplan, MDVideo: The Endocannabinoid System’s Intriguing Role in Gut Health
read more

CBD antibacterial properties, topically

Preliminary testing shows positive results towards using CBD as an antibiotic topically, but also potentially to deal with systematic infections, such as pneumonia, using oral dosing. One of the present concerns is the struggle of getting permits to handle these cannabinoids to do further testing.

While these specific findings have not yet been published in a peer-review journal, this is far from the first time we have seen antimicrobial activity associated with plants or with cannabis. Evolutionarily, this trait is believed to be adaptive for the plant, and within cannabinoid, terpenoid, and flavonoid compounds, this activity has been demonstrated reproducibly, both in the lab and in clinic.
http://bit.ly/2LbTwxm

To explore related information, check the CED Foundation MMJ archive to search, or click the keywords below:

Benjamin Caplan, MDCBD antibacterial properties, topically
read more

Video: Cannabis and Multiple Sclerosis

A 2019 literature review summarizes the findings on cannabis use for patients with multiple sclerosis. Cannabis has been shown to aid a number of symptoms associated with multiple sclerosis, including chronic pain, spasticity, and problems with sleep. To learn more, check out our video adaptation below:

View this review (yellow link) or download:

This paper is also stored here:     http://bit.ly/2IJAqNz    inside the CED Foundation Archive

To explore related information, click the keywords below:

Benjamin Caplan, MDVideo: Cannabis and Multiple Sclerosis
read more

Cannabis constituent synergy in a mouse neuropathic pain model

In a mice-model study, researchers found that low dose THC:CBD might successfully treat neuropathic pain. 

Neuropathic pain is pain caused by damage to the somatosensory nervous system. Neuropathic pain may be associated with abnormal sensations or pain from normally non-painful stimuli, for example, Phantom Limb Syndrome.

View this review (yellow link) or download:

This paper is also stored here:   http://bit.ly/2Fk0yw7      inside the CED Foundation Archive

To explore related information, click the keywords below:

Benjamin Caplan, MDCannabis constituent synergy in a mouse neuropathic pain model
read more