Flavonoids

Atriplex Tatarica Flavonoids Show Anti-Bacterial and Anti-Biofilm Activity

 Investigation into the flavonoid derivatives of Atriplex tatarica shows that it provides anti-bacterial and anti-biofilm potential against Pseudomonas aeruginosa.

P. aeruginosa is a bacterium that causes infections most frequently in immunocompromised individuals who have been hospitalized for long periods of time. A biofilm is a protective shield that some types of bacteria create for themselves in attempt to protect against host immune system defenses. An infection that evades an immune system can become quickly dangerous should bacterial or biofilm grow in the lungs, kidney, or urinary tracts. Incorporating the flavonoids found in A. tatarica into medical regimen could provide an option for augmenting current treatment for antibiotic-resistant infections. The growth of biofilms, or collections of microorganisms that can grow on a wide variety of surfaces, makes the treatment of Pseudomonas aeruginosa in hospitalized patients with antibiotics markedly more difficult. Certain flavonoids with proven anti-bacterial and anti-biofilm provide an alternative route for helping to manage deadly antibiotic-resistant infections.

Atriplex hortensis cleaned Sturm.png
Image result for Teutliopsis

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Benjamin Caplan, MDAtriplex Tatarica Flavonoids Show Anti-Bacterial and Anti-Biofilm Activity
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The Relationship of Flavonoid Intake During Pregnancy With Excess Body Weight and Gestational Diabetes Mellitus

 Consuming Food Rich in Flavonoids Can Reduce Excess Body Weight During Pregnancy

In Summary

A recent study has found that women who consume food rich in flavonoids during pregnancy (found in fruits, vegetation, and also in cannabis, tend to have less excess body weight. European studies have also reported that flavonoid-rich diets during pregnancy can reduce the risk of gestational Diabetes Mellitus (GDM) but their studies recorded women consuming even higher amounts of flavonoids that the women in the American study. A meta-analysis of American and European studies confirms that pregnant women who maintain a flavonoid-rich diet have an easier time managing the excess weight associated with pregnancy. 

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Benjamin Caplan, MDThe Relationship of Flavonoid Intake During Pregnancy With Excess Body Weight and Gestational Diabetes Mellitus
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The Dietary Flavonoid, Luteolin, Negatively Affects Neuronal Differentiation

In Summary:

The Importance of Chemical Structure: Functional Groups of Flavonoids

A recent study has revealed the detrimental effects of the flavonoid luteolin on neuronal differentiation in embryonic stem cells. Luteolin is a dietary flavonoid that has been researched due to its anti-cancer, antioxidant, and anti-inflammatory actions and is now being looked into for its supposed neuroprotective qualities. This study found that although luteolin does have some neuroprotective benefits it also has harmful side effects on neuronal development.  Apigenin is a similar flavonoid that also has neuroprotective qualities but does not disrupt differentiation, emphasizing how slight differences in chemical structure can change the effects of a flavonoid. 



image of The Dietary Flavonoid, Luteolin, Negatively Affecting Neuronal Differentiation
images of Luteolin Negatively Affecting Neuronal Differentiation

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Benjamin Caplan, MDThe Dietary Flavonoid, Luteolin, Negatively Affects Neuronal Differentiation
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A Flavonol from Sweetscented Marigold Alleviates Pain

Tagetes Lucida as a potential analgesic

In Summary:

Researchers have recently provided evidence that a flavonol extract derived from a common flower has antinociceptive (pain-relieving) properties. Sweet-scented Marigold has been used is frequently used in cooking techniques in South America and has now been found to alleviate pain through serotonin and opioid mechanisms of action. The antinociceptive properties of this flavonol, like those of many other plant-derived compounds, are ripe for testing in a clinical setting to determine their effectiveness in human patients. In this small animal study, it clearly demonstrates promise as a safe alternative to commonly used pain medications. 

Dr. Caplan and the #MDTake:

Modern medicine seems to have largely forgotten its roots. Long before pharmaceutical companies were the source of all medication, the earth served as a resource for medications, and apothecaries, pharmacists, and druggists, as they were known, supported the medical industry with formulations and a deep understanding of natural resources. As the greater scientific arena and dominant culture have lost touch with the earth’s natural medicinal resources, our culture has lost a deeply valuable reservoir of opportunity. As the fast-paced life of modernity demands faster results on an ever-greater, mass-production scale, the construction of sprawling cities, which often demands deforestation and destruction of natural resources, may turn out to be a greater threat to human health than most of us have yet to even understand.

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Benjamin Caplan, MDA Flavonol from Sweetscented Marigold Alleviates Pain
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Flavonoids Proven to be Safe and Effective Treatment for Chronic Venous Disease

Recommendations for the medical management of chronic venous disease- The role of Micronized Purified Flavonoid Fraction (MPFF)

In Summary:

A recent review has affirmed that treating chronic venous disease with Micronized Purified Flavonoid Fraction (MPFF) therapy is safe and effective. After reviewing 250 papers, the authors have found a large body of supportive evidence that the MPFF treatment, known as Diosmiplex, is effective for healing venous ulcers on its own or in combination with compression therapy. Diosmiplex, the only MPFF prescribed in the United States, as of 2017, is derived from orange rinds and favorable among patients due to its high safety rating. 

Dr. Caplan and the #MDTake:

Flavonoids are one of the categories of natural compounds produced in nature, including within the innate production system of the cannabis plant. Several patients have reported using strong cannabis topical agents to help venous insufficiency and disease, including conditions such as varicose veins, phlebitis, and post-surgical venous incompetence.

varicose veins picture

Process of leukocyte trapping to tissue degradation
contributing factors to  skin pathology and edema
Genetic and environmental risk factors for CVD
US and European Guideline Recommendations that include flavonoids  and MPFF
Cellular Molecular pathology of venous hypertension
CVI Symptom Assessment
WBC adhesion  with venous hypertension
Recommendations for the use of MPFF in the management of chronic venous disease

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Benjamin Caplan, MDFlavonoids Proven to be Safe and Effective Treatment for Chronic Venous Disease
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Flavonoid Treatment for Pancreatic Cancer?

“Study on cannabis chemical as a treatment for pancreatic cancer may have ‘major impact,’ Harvard researcher says”

The article:

https://yhoo.it/2TQw0bo


The Science:

Abstract:

“Pancreatic cancer is particularly refractory to modern therapies, with a 5-year survival rate for patients at a dismal 8%. One of the significant barriers to effective treatment is the immunosuppressive pancreatic tumor microenvironment and development of resistance to treatment. New treatment options to increase both the survival and quality of life of patients are urgently needed. This study reports on a new non-cannabinoid, non-psychoactive derivative of cannabis, termed FBL-03G, with the potential to treat pancreatic cancer. In vitro results show major increase in apoptosis and consequential decrease in survival for two pancreatic cancer models- Panc-02 and KPC pancreatic cancer cells treated with varying concentrations of FBL-03G and radiotherapy. Meanwhile, in vivo results demonstrate therapeutic efficacy in delaying both local and metastatic tumor progression in animal models with pancreatic cancer when using FBL-03G sustainably delivered from smart radiotherapy biomaterials. Repeated experiments also showed significant (P < 0.0001) increase in survival for animals with pancreatic cancer compared to control cohorts. The findings demonstrate the potential for this new cannabis derivative in the treatment of both localized and advanced pancreatic cancer, providing impetus for further studies toward clinical translation.

Discussion highlights:

“From the results of this study, the key findings include, observation that a non-cannabinoid derivative of cannabis can enhance radiotherapy treatment outcomes in-vitro and in-vivo as highlighted in Figures 2, 4. Secondly, the sustained delivery of the cannabis derivative FBL-03G from smart radiotherapy biomaterials (SRBs) results in tumor growth inhibition of both locally treated and distant untreated tumors, with and without radiotherapy. The use of smart radiotherapy biomaterials (SRBs) (8, 23) was recently proposed as a novel approach to deliver cannabinoids, allowing for prolonged exposure of tumor cells to these cannabis derivatives, which is expected to be more effective (10). The FBL-03G payload used in this study is a flavonoid non- cannabinoid derivative of cannabis, and the potential to inhibit both local and metastatic tumor progression is remarkable, especially for pancreatic cancer, with a dismal 5-year survival rate of 8% (1).”

“While the results indicate that sustained exposure of tumor cells to FBL-03G can boost both local and metastatic tumor cell kill, the mechanism of such action needs to be further investigated. One hypothesis is that, FBL-03G can serve as an immunotherapy agent, inhibiting growth of locally treated and untreated tumors, representing metastasis. Metastasis accounts for most of all cancer-associated suffering and death, and questionably presents the most daunting challenge in cancer management. Henceforth, the observed significant increase in survival is promising, especially for pancreatic cancer which is often recalcitrant to treatments. Another hypothesis is that sustained delivery allows FBL-03G to reach the untreated tumor over a prolonged period as well. Either way, the FBL-03G results reveal a new potential non-cannabinoid cannabis derivative with major potential for consideration in further investigations in the treatment of pancreatic cancer, where new therapy options are urgently needed.”

Dr Caplan’s Take:

This article is one in a growing collection of impressive data that highlights a critical area of Medicine that has hidden from the scientific community for decades. The goal of the review is NOT to hail praise on cannabis as a panacea, nor even a sole treatment option, for pancreatic cancer. Rather, it highlights that it seems to be working effectively, both in living tumor cells in the lab and in animal models with live tumor cells. For a devastating illness that currently carries a grim prognosis, the proposition here is to learn more.

The milestones between pioneering scientific study and effective medication are many and there is much work to be done. Studies must be reviewed, criticized, replicated, integrated, before pioneering products can be developed, produced, tested, scaled, brought to market, marketed, sold, and consumed. The process is long, but at least there is a seed of hope at the beginning!

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This paper is also stored here:   http://bit.ly/2TPSY2t      inside the CED Foundation Archive

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Benjamin Caplan, MDFlavonoid Treatment for Pancreatic Cancer?
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Flavonoids as Pain Relief

Forget CBD; flavonoids found in cannabis have been found to be 30 times more effective painkillers than aspirin, targeting inflammation at the source and making them great alternatives for pain killers. If produced on a larger scale, they could help get away from the opioid crisis.

http://bit.ly/2TbAxoG

Here, a folder w/ hundreds more specific reviews of the medical benefits of flavonoids: http://bit.ly/2XugfvI

Benjamin Caplan, MDFlavonoids as Pain Relief
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How to store cannabis

If stored properly, cannabis can last up to two years.
We are starting to see ground-breaking technology rising in the industry, including filtration of humidity built into packaging, as well as permeable membranes that support the wise guarding of both hydration and terpene/flavonoid concentration.

https://www.leafly.com/news/cannabis-101/how-long-is-my-cannabis-good-for-leaflys-guide-to-storing-cannabi

Benjamin Caplan, MDHow to store cannabis
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Do-it-Yourself Cannabis-infused lubricants

Cannabis-infused lubricant can increase blood flow for men and create full-body experiences for women. Find out how to make your own infused lube at home with this video tutorial!

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Benjamin Caplan, MDDo-it-Yourself Cannabis-infused lubricants
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Video: Do-It-Yourself Cannabis Tinctures

One of the terrific realities of modern Cannabis is that it is possible, and often quite simple, to make effective products at home. With suitable education and access to testing facilities, the soil, nutrients, and plant growth can be supported at home, lab-tested for make-up and potency, as well as safety-checked for potential microscopic contaminants, and ultimately, individualized medicine can be created right at home!

Here is a sample instructional for just one way that cannabis tincture can be made at home. There are countless others and hopefully, many that are yet to be discovered!

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Benjamin Caplan, MDVideo: Do-It-Yourself Cannabis Tinctures
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