Effect of citrus peel extracts on the cellular quiescence of prostate cancer cells
A recent study has revealed that citrus peel extracts (CPE) have the potential to prevent prostate cancer from recurring in post-therapy cancer patients. A component of CPE, flavonoids, have previously been found to have anticancer effects, but appear to lack the correct structure to prevent tumors in patients with prostate cancer. This specific study found that the citric acid present in CPE was the contributing factor to its anticancer effects but mentioned that flavonoids should continue to be researched for chemopreventive benefits.
A recent study has found that flavonoids isolated from Psoralea corylifolia are able to inhibit part of the insulin pathway.
Seeds of the P. corylifolia plant have been used in eastern medicine, primary in China, for years, and is now being further researched as flavonoids continue to intrigue researchers with their possible therapeutic benefits. The inhibitory activity found in this study provides evidence that flavonoids should be pursued as a potential treatment for Type-2 Diabetes.
Citrus peels waste as a source of value-added compounds- extraction and quantification of bioactive polyphenols
A recent study has exposed a more efficient, sustainable, and economically viable extraction method for polyphenols (specific active chemical compounds) from citrus peels. One such polyphenol is Naringin, a flavonoid present in lemon peels, which has been hypothesized to have anti-inflammatory and antioxidant effects, as well as, potentially, to help treat obesity. This new extraction method will allow researchers to discover more definite therapeutic effects of polyphenols in citrus peels.
Evaluation of the Anti-inflammatory and Antioxidative Potential of Four Fern Species from China Intended for Use as Food Supplements:
Four fern species, Matteuccia struthiopteris, Osmunda japonica, Matteuccia orientalis, and Pteridium aquilinum are food sources, commercially available on Chinese markets. In a recent study investigating the medicinal properties of select plants, these four ferns were also found to have anti-inflammatory and anti-oxidative properties. All four ferns inhibit expression of IL1-β, a pro-inflammatory gene. These results support an investigation of other common wild edible plants with respect to their potential for medicinal use.
Cannabis may just open up a refreshing look at countless other plants available to those who appreciate the opportunity.
Silymarin is a natural compound called a flavonoid, which happens to have antioxidant and liver protecting activities. Over many years, it has been proposed as a complementary medicine to reduce the liver injury produced by other medications. Interestingly, it happens to have anti-inflammatory properties and the ability to kill some bacteria. This flavonoid, Silymarin, is found in Milk Thistle… as well as Cannabis..and it seems to have “a significant therapeutic effect administered alone, or in combination with chemotherapy, in [helping to treat] tuberculosis caused by drug-sensitive or drug-resistant strains[, findings represented here in both] in vitro and in vivo studies”
For many years, Tuberculosis (TB) has been a devastating public health problem, internationally. The treatment of this bacteria has been very limited and loaded with challenges. There is a constant cat/mouse chase between nature and human medicine, as the bacteria continually evolves to out-compete new drugs that are developed to treat it.
Here, yet another amazing potential breakthrough that cannabis brings to the table. Among the other flavonoids besides Silymarin: Orientin, Quercetin, and Kaempferol.
Of note: Silymarin happens to inhibit some liver enzymes, CYP-3A4 and CYP-2C9, which happen to be some of the liver enzymes which help break down cannabis metabolites.
I wonder if we should be spending as much time on flavonoids as we do on terpenes (including cannabinoids)?
There is little doubt that they play a powerful effect. Just as the minor cannabinoids tend to be overlooked by much of the general & scientific cultures… flavonoids are also largely passed-over.
This study, for example, indicates that some of the components of dark chocolate reduce the body’s production of the stress hormone, cortisol (not surprising to most who have every consumed chocolate, but… did you know that those components are also found all over nature, including inside cannabis?!)
I’ll start adding flavonoids to the list of info to start sharing!