Title: Novel approaches in clinical development of cannabinoid drugs
A pamphlet has recently been published that highlights new approaches in the clinical development of cannabinoid-based therapies. The pamphlet begins with a look into how current cannabinoids affect patients based on gender, stress, physiological variations, and also delves into how cannabis works on the body in general.
A novel therapy that features an oral version of tetrahydrocannabinol (THC) and a synthetic activator of cannabinoid-receptor-1 (CB1) is explored in this piece and frames it to be a promising future therapy. The pharmacological properties of these two novel therapies were optimized during development after various analysis techniques, forming medications that the authors hope to see in future clinical trials.
Although the authors remain hopeful that their cannabis-based therapies will reach clinical trials soon, trials featuring cannabinoids are difficult to test in a formal setting because of a dire lack of funding. The federal government still lists cannabis as a Schedule I substance, under the Controlled Substances Act, meaning that the federal government does not support the idea that cannabis has any medical use. Considering the legal status of cannabis, only privately-funded studies are able to take place, and unfortunately, that leaves cannabis research in an area of complete bias and prohibitively underfunded. Considering the massive literature supporting a myriad of novel therapeutic benefits, this is a costly reality to the health and well-being of millions.
Title: Impact of N, P, K and humic acids supplementation on the chemical profile of medical cannabis (Cannabis sativa L)
A recent study has come out revealing the effects of nutritional supplements (plant food) on cannabinoid content during the growth of the cannabis plant.
Researchers enhanced nutritional supplements such as humic acids and inorganic nitrogen and potassium and determined that the changes in supplement levels caused variations in the cannabinoid content of the plant organs. This research has demonstrated that maintaining specific nutritional supplements effects the chemical properties of cannabis plants and may play a role in standardizing the cannabinoid content in plants, no matter the region of growth. This knowledge may one day help cultivators with the process of standardizing cultivars, and perhaps help organize strain names and content across state lines.
This work spotlights the inconsistency between cannabis plants, even if they share the same name. The nutrients cannabis plants grow in have been proven to alter the cannabinoid content which changes (sometimes drastically) the effects felt by patients who consume that plant. Growers or enthusiasts who grow cannabis at home may be buying seeds from a known strain, but the same seeds produce a completely different strain, depending on the growing conditions. Standardizing growth conditions will hopefully help cultivators produce strains of the same name with consistent cannabinoid content, making buying safer and somewhat more uniformly regulatable.
Tweet: A recent study has come out revealing the effects of #nutritional supplements on #cannabinoid content during #cannabis plant growth. Read this and other linked studies:
One of the terrific realities of modern Cannabis is that it is possible, and often quite simple, to make effective products at home. With suitable education and access to testing facilities, the soil, nutrients, and plant growth can be supported at home, lab-tested for make-up and potency, as well as safety-checked for potential microscopic contaminants, and ultimately, individualized medicine can be created right at home!
Here is a sample instructional for just one way that cannabis tincture can be made at home. There are countless others and hopefully, many that are yet to be discovered!
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Benjamin Caplan, MDVideo: Do-It-Yourself Cannabis Tinctures