Muscle Pain

Alcohol Hangover Has Detrimental Impact Upon Both Executive Function and Prospective Memory

In a study that excluded cannabis users, researchers found that alcohol hangovers significantly impair both executive function (paying attention, regulating emotions, etc.) and prospective memory (remembering future plans).

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This paper is also stored here:    http://bit.ly/31paJsL     inside the CED Foundation Archive

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Benjamin Caplan, MDAlcohol Hangover Has Detrimental Impact Upon Both Executive Function and Prospective Memory
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Synthetic Cannabinoids Provide Evidence for Targeting Cannabinoid Receptors in the Treatment of Autoimmune Diseases

Pharmaceutical Cannabis Derivatives Help Discover their Receptors and Functions for Autoimmune Illnesses

A recent study conducted by Michigan State University exposed the potential for cannabinoid receptor 2 (CB2) to target the treatment of inflammatory conditions. Elevated levels of plasmacytoid dendritic cells (pCD, a type of cell in the immune system) contribute to chronic inflammation in autoimmune diseases, such as Rheumatoid Arthritis. Researchers found that synthetic CB2 agonists reported comparable benefits to THC, but minimized the cerebral effects as the psychotropic activity is mediated by cannabinoid receptor 1 (CB1). This evidence demonstrates the potential benefits of CB2-targeted treatment for inflammatory conditions. Unfortunately, there are serious concerns about the misuse of some synthetic cannabinoids, so there is still a missing bridge, in products and public education, between these research products and potential therapeutic pharmaceuticals, down the road.

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This paper is also stored here:  http://bit.ly/2HZ6cWb  inside the CED Foundation Archive

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Benjamin Caplan, MDSynthetic Cannabinoids Provide Evidence for Targeting Cannabinoid Receptors in the Treatment of Autoimmune Diseases
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Some, But Not Enough Data on Cannabis for Chronic Pain

Overlaps in pharmacology for the treatment of chronic pain and mental health disorders

Select small trials have demonstrated cannabis to be more effective than other analgesics to treat chronic pain associated with certain conditions. However, the existing research lacks large-scale, controlled experiments relating medical cannabis use to pain management. Additionally, negative effects are documented with respect to cannabis use among adolescents and those suffering from compromised mental health. There is a need for further research on the topic.

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This paper is also stored here: http://bit.ly/2wtvpRY inside the CED Foundation Archive

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Benjamin Caplan, MDSome, But Not Enough Data on Cannabis for Chronic Pain
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Video: Medical Marijuana: What Physicians Need to Know

A video adaptation of “Medical Marijuana: What Physicians Need to Know” (http://bit.ly/2KxqoAe) https://drive.google.com/file/d/11S1vyQkAdeoDcYzToKyTXGG3y3ZmVnHI/view

Benjamin Caplan, MDVideo: Medical Marijuana: What Physicians Need to Know
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Sativex Reduces MS-Related Spasticity

Delta-9-Tetrahydrocannabidiol Oromucosal Spray (Sativex): A Review in Multiple Sclerosis-Related Spasticity

A debilitating symptom of multiple sclerosis (MS) is spasticity, the stiffness and involuntary spasms of muscles, often occurring in the legs. In a randomized study involving MS patients who have not experienced relief with any current anti-spasticity medication, Sativex, a THC/CBD oro-mucosal spray was administered. Patients receiving THC/CBD experienced significantly more spasticity relief than the placebo group. Sativex may hold substantial treatment potential for MS patients, as side effects are minimized, the spray allows for an adjustable dosage, and there is low potential for abuse.

While this pharmaceutical is proving to be effective, in related data, we also see a distinct advantage of non-pharmaceutical options, including cost, availability, and efficacy, although drastically higher variability and limited consistency in product.

http://bit.ly/2WwVoqA

Benjamin Caplan, MDSativex Reduces MS-Related Spasticity
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