A recent study has revealed that the co-activation of mu-opioid receptors and cannabinoid receptor 1 (CB1) results in the attenuation of the response seen when each receptor type is activated on its own. The decreased response of the two receptor types during co-activation has been implicated in negatively modulating neuritogenesis (the process of generating new brain nerve cells). Neuritogenesis is important for the cells’ ability to receive and project signals leading the researchers to call for more research in order to elucidate the effect this may have on addiction.
The fact that there is co-interaction between opioid receptors and cannabinoid receptors is also interesting to inform the discussion of the place that cannabinoid actors may have in supporting the healing of those who are dependent or addicted to opiate medications.
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