Neuropathy

Efficacy of Cannabinoids in a Pre-Clinical Drug-Screening Platform for Alzheimer’s Disease

Researchers find 9 cannabinoids that might protect the brain against toxicities associated with aging. These non-intoxicating cannabinoids are potential drug candidates for Alzheimer’s Disease, and they might also be options for other neurodegenerative diseases, too

View this review (yellow link) or download:

This paper is also stored here:     http://bit.ly/2L9GccX    inside the CED Foundation Archive

To explore related information, click the keywords below:

Benjamin Caplan, MDEfficacy of Cannabinoids in a Pre-Clinical Drug-Screening Platform for Alzheimer’s Disease
read more

Medical Marijuana and Treatment of Pediatric Epilepsy Patients

Medical Marijuana in the Pediatric Population With Epilepsy—What You Should Know

A recent review has discussed the known benefits of treating children who are suffering from epilepsy with cannabis-based medicine. Medical marijuana (MM) is a viable option for treating this population that comes with risks due to the high that comes from THC and its legal status as a Schedule 1 drug. The legal status is currently preventing larger scale research to be done so that physicians can better educate parents on how to care for a child taking MM.

View this review (yellow link) or download:

This paper is also stored here:     http://bit.ly/2KNbGVS    inside the CED Foundation Archive

To explore related information, click the keywords below:

Benjamin Caplan, MDMedical Marijuana and Treatment of Pediatric Epilepsy Patients
read more

Honey and Garlic Help Heal Burn Wounds

Euphorbia honey and garlic- Biological activity and burn wound recovery

A recent study has shown that a combination of euphorbia honey and garlic can help heal burn wounds. Euphorbia honey and garlic have antioxidant, microbial, and healing properties that have now been confirmed to be effective when treating wounds resulting from exposure to extreme heat. Combining natural ingredients has been common in traditional medicine for years, but now western medicine is beginning to look at more natural compounds to aid in recovery and treatment methods.

This paper is also stored here:  http://bit.ly/2Fbqk5F   inside the CED Foundation Archive

View this review (yellow link) or download:

To explore related information, click the keywords below:

Benjamin Caplan, MDHoney and Garlic Help Heal Burn Wounds
read more

Evidence for Therapeutic Benefits of Cannabidiol, Including Treatment of Ischemic Strokes

Therapeutic Potential of Non-Psychotropic Cannabidiol in Ischemic Stroke

Cannabidiol (CBD) has a unique therapeutic profile as it has a cannabinoid receptor-independent mechanism, limited side-effects, and patients do not seem to develop an insurmountable tolerance. Research currently focussed on the therapeutic benefits of CBD has demonstrated long-lasting neuroprotective properties against global and focal ischemic injury, such as ischemic stroke. This piece points to CBD as a major component of cannabis-based medicine as a non-psychoactive component. Further research is needed to evaluate the full clinical capabilities of CBD, including its neuroprotective effect.

View this review (yellow link) or download:

The US patent on Cannabinoids as Antioxidants and Neuroprotectants, from 1999: https://patents.google.com/patent/US6630507B1/en

This paper is also stored here:    http://bit.ly/2L0PBn3     inside the CED Foundation Archive

To explore related information, click the keywords below:

Benjamin Caplan, MDEvidence for Therapeutic Benefits of Cannabidiol, Including Treatment of Ischemic Strokes
read more

The Education of Dispensary Staff is Varied and Lacks Regulation

Training and Practices of Cannabis Dispensary Staff

How much medical training does your local budtender possess? An online survey sent to medical marijuana dispensary staff reported only 55% of staffers had any formal training for their position, with 20% reporting some background in medical/scientific training. The analysis reported that many among the dispensary staff are recommending cannabis choices that are consistent with current evidence, but some are recommending strains that are either ineffective or exacerbate a patient’s condition. The findings of this study stress the importance of consistent and well-regulated training of dispensary staff.

View this review (yellow link) or download:

This paper is also stored here:    http://bit.ly/2FfJNSC     inside the CED Foundation Archive

To explore related information, click the keywords below:

Benjamin Caplan, MDThe Education of Dispensary Staff is Varied and Lacks Regulation
read more

A 2018 study finds that cannabis can alleviate symptoms of medications used for chronic pain as well as serve as an alternative treatment for seizures, pain, and inflammation.

Benjamin Caplan, MDA 2018 study finds that cannabis can alleviate symptoms of medications used for chronic pain as well as serve as an alternative treatment for seizures, pain, and inflammation.
read more

Synthetic Cannabinoids Provide Evidence for Targeting Cannabinoid Receptors in the Treatment of Autoimmune Diseases

Pharmaceutical Cannabis Derivatives Help Discover their Receptors and Functions for Autoimmune Illnesses

A recent study conducted by Michigan State University exposed the potential for cannabinoid receptor 2 (CB2) to target the treatment of inflammatory conditions. Elevated levels of plasmacytoid dendritic cells (pCD, a type of cell in the immune system) contribute to chronic inflammation in autoimmune diseases, such as Rheumatoid Arthritis. Researchers found that synthetic CB2 agonists reported comparable benefits to THC, but minimized the cerebral effects as the psychotropic activity is mediated by cannabinoid receptor 1 (CB1). This evidence demonstrates the potential benefits of CB2-targeted treatment for inflammatory conditions. Unfortunately, there are serious concerns about the misuse of some synthetic cannabinoids, so there is still a missing bridge, in products and public education, between these research products and potential therapeutic pharmaceuticals, down the road.

View this review (yellow link) or download:

This paper is also stored here:  http://bit.ly/2HZ6cWb  inside the CED Foundation Archive

To explore related information, click keywords:

Benjamin Caplan, MDSynthetic Cannabinoids Provide Evidence for Targeting Cannabinoid Receptors in the Treatment of Autoimmune Diseases
read more

Some, But Not Enough Data on Cannabis for Chronic Pain

Overlaps in pharmacology for the treatment of chronic pain and mental health disorders

Select small trials have demonstrated cannabis to be more effective than other analgesics to treat chronic pain associated with certain conditions. However, the existing research lacks large-scale, controlled experiments relating medical cannabis use to pain management. Additionally, negative effects are documented with respect to cannabis use among adolescents and those suffering from compromised mental health. There is a need for further research on the topic.

View this review (yellow link) or download:

This paper is also stored here: http://bit.ly/2wtvpRY inside the CED Foundation Archive

To explore related information, click keywords:

Benjamin Caplan, MDSome, But Not Enough Data on Cannabis for Chronic Pain
read more

Video: Medical Marijuana: What Physicians Need to Know

A video adaptation of “Medical Marijuana: What Physicians Need to Know” (http://bit.ly/2KxqoAe) https://drive.google.com/file/d/11S1vyQkAdeoDcYzToKyTXGG3y3ZmVnHI/view

Benjamin Caplan, MDVideo: Medical Marijuana: What Physicians Need to Know
read more

Sativex Reduces MS-Related Spasticity

Delta-9-Tetrahydrocannabidiol Oromucosal Spray (Sativex): A Review in Multiple Sclerosis-Related Spasticity

A debilitating symptom of multiple sclerosis (MS) is spasticity, the stiffness and involuntary spasms of muscles, often occurring in the legs. In a randomized study involving MS patients who have not experienced relief with any current anti-spasticity medication, Sativex, a THC/CBD oro-mucosal spray was administered. Patients receiving THC/CBD experienced significantly more spasticity relief than the placebo group. Sativex may hold substantial treatment potential for MS patients, as side effects are minimized, the spray allows for an adjustable dosage, and there is low potential for abuse.

While this pharmaceutical is proving to be effective, in related data, we also see a distinct advantage of non-pharmaceutical options, including cost, availability, and efficacy, although drastically higher variability and limited consistency in product.

http://bit.ly/2WwVoqA

Benjamin Caplan, MDSativex Reduces MS-Related Spasticity
read more