How to prevent inappropriate teen use?

Especially in Colorado and Washington, people are taking note of teens’ use and access to potent marijuana, and many are concerned that there are not enough measures in place to prevent this. Newly legalized states should look into this before it becomes a national issue.

Benjamin Caplan, MDHow to prevent inappropriate teen use?
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Common Concerns for cannabis CEOs

When the CEOs of major cannabis companies were asked what they believed the biggest threats to the cannabis industry are, the answers were consistent with common concerns: black market cannabis, public policy, execution of businesses, as well as consistency of product and markets. Not only in the US, but also globally

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Benjamin Caplan, MDCommon Concerns for cannabis CEOs
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News: Medical dispensaries vs Recreational

As more states begin to legalize cannabis recreationally, the number of medical patients drops rapidly. Higher costs, fewer shops, and the removal of some products for ones with a wider appeal can make it difficult for patients to get the medication they have been relying on.

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Benjamin Caplan, MDNews: Medical dispensaries vs Recreational
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The Netherland’s History with Medical Marijuana

A video adaptation of “Key elements of legal environments for medical use of cannabis” that details The Netherland’s history with medical marijuana.

Benjamin Caplan, MDThe Netherland’s History with Medical Marijuana
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Countering the Modern Metabolic Disease Rampage With Ancestral Endocannabinoid System Alignment

Cannabinoid receptors, located throughout the body, are involved in a variety of physiological processes (including appetite, mood, etc.). A 2019 study shows that blocking CB1Rs (cannabinoid receptors that conserve energy) is an effective way to manage metabolic disorders, such as obesity and Type-2 Diabetes. 

View this review (yellow link) or download:

This paper is also stored here:     inside the CED Foundation Archive

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Benjamin Caplan, MDCountering the Modern Metabolic Disease Rampage With Ancestral Endocannabinoid System Alignment
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Dr Caplan & Dr Grinspoon meet with Wiley’s Alcohol and Drug Abuse Weekly

It was a privilege to meet with the editor of Wiley Publishing Company’s Alcohol and Drug Abuse Weekly, Dr Peter Grinspoon, and a select group of MA dispensary representatives this weekend, to discuss our shared goals & plan to support global access to education, of physicians, the #MedicalCommunity, the #CannabisIndustry, and the #CannabisCommunity.

Benjamin Caplan, MDDr Caplan & Dr Grinspoon meet with Wiley’s Alcohol and Drug Abuse Weekly
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Edibles: Tasty or Not Tasty?

Edibles are a popular way to consume cannabis because they can be tasty & easy, but maybe this is a problem? Should meds be made unappealing to children or pets? Although many people enjoy treatment via gummy bears, is this a bad path? The Brilliant Dr Peter Grinspoon’s take:

The following is an interesting perspective from Julie Beck @

Some interesting related points to consider:

Taste buds likely evolved to detect foods which have a positive (or negative) effect on the body. It seems logical to assume that good taste would prime good effects. Also, cannabis has an effect similar to hypnotizability and suggestibility. If it tastes good, it’s logical to suggest that good tastes would suggest a higher likelihood of improved effect, from a psychological standpoint too.

A counter-argument: “If it tastes good, people (especially kids) would take it all the time. It actually should taste unpleasant so that you only take it when the alternative is worse.”

1 – Better-tasting medications may enhance pediatric adherence to drug therapy, where that is appropriate. 

2 – Sugars, acids, salt, and other substances may reduce perceived unpleasant taste of cannabis With respect to children, in one study, more than 90% of pediatricians suggested that a drug’s taste and palatability were the biggest barriers to completing treatment. 

3 – The potential for taste stimuli to activate nongustatory sensory systems, including those of a visceroceptive nature in the cases where the taste solutions are swallowed, must be considered, particularly as bitter tastes (likely with cannabis) are governed by GPR protein receptors.

4 – Pleasant tasting products activate a conditioned response:  good taste = good effect (when can then generalized to all pleasant-tasting edibles.

5 – “The unpleasant taste of medicine is often a sensory expression of its pharmacological activity; in many cases, the more potent the drug, the more bitter it will be. The more bitter, the more likely the drug will be rejected. Better-tasting medications may go a long way toward enhancing the ability of pediatric patients to adhere to drug therapy, especially when failure to consume may do harm and, in some cases, be life-threatening.” 

6 – On the other hand, frequent use of sucrose-sweetened medicines has been linked to dental caries 

Benjamin Caplan, MDEdibles: Tasty or Not Tasty?
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Misleading Headlines of THC “overdose”

Misleading headlines make it seem like this woman may have died of THC overdose, however, we know that it would be nearly impossible to consume lethal amounts of THC, and the coroner clearly made vague, and incomplete assumptions. This, likely feeding into a comfortable, though quite false stigma around cannabis.

Benjamin Caplan, MDMisleading Headlines of THC “overdose”
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Market Projections, Ethanol Extraction, and Mismatched Expectations

While most people tout market projections, this CEO notes that many people entering the industry have not considered the logistics behind creating and expanding their business. In such a unique industry, realistic goals and measures will be crucial to long term success and scaling.

Benjamin Caplan, MDMarket Projections, Ethanol Extraction, and Mismatched Expectations
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