It was a privilege to meet with the editor of Wiley Publishing Company’s Alcohol and Drug Abuse Weekly, Dr Peter Grinspoon, and a select group of MA dispensary representatives this weekend, to discuss our shared goals & plan to support global access to education, of physicians, the #MedicalCommunity, the #CannabisIndustry, and the #CannabisCommunity.
Benjamin Caplan, MDDr Caplan & Dr Grinspoon meet with Wiley’s Alcohol and Drug Abuse Weekly
Edibles are a popular way to consume cannabis because they can be tasty & easy, but maybe this is a problem? Should meds be made unappealing to children or pets? Although many people enjoy treatment via gummy bears, is this a bad path? The Brilliant Dr Peter Grinspoon’s take: http://bit.ly/2KygQov
Taste buds likely evolved to detect foods which have a positive (or negative) effect on the body. It seems logical to assume that good taste would prime good effects. Also, cannabis has an effect similar to hypnotizability and suggestibility. If it tastes good, it’s logical to suggest that good tastes would suggest a higher likelihood of improved effect, from a psychological standpoint too.
A counter-argument: “If it tastes good, people (especially kids) would take it all the time. It actually should taste unpleasant so that you only take it when the alternative is worse.”
1 – Better-tasting medications may enhance pediatric adherence to drug therapy, where that is appropriate.
2 – Sugars, acids, salt, and other substances may reduce perceived unpleasant taste of cannabis With respect to children, in one study, more than 90% of pediatricians suggested that a drug’s taste and palatability were the biggest barriers to completing treatment.
3 – The potential for taste stimuli to activate nongustatory sensory systems, including those of a visceroceptive nature in the cases where the taste solutions are swallowed, must be considered, particularly as bitter tastes (likely with cannabis) are governed by GPR protein receptors.
4 – Pleasant tasting products activate a conditioned response: good taste = good effect (when can then generalized to all pleasant-tasting edibles.
5 – “The unpleasant taste of medicine is often a sensory expression of its pharmacological activity; in many cases, the more potent the drug, the more bitter it will be. The more bitter, the more likely the drug will be rejected. Better-tasting medications may go a long way toward enhancing the ability of pediatric patients to adhere to drug therapy, especially when failure to consume may do harm and, in some cases, be life-threatening.”
6 – On the other hand, frequent use of sucrose-sweetened medicines has been linked to dental caries
Misleading headlines make it seem like this woman may have died of THC overdose, however, we know that it would be nearly impossible to consume lethal amounts of THC, and the coroner clearly made vague, and incomplete assumptions. This, likely feeding into a comfortable, though quite false stigma around cannabis. http://bit.ly/31iwwlK
Benjamin Caplan, MDMisleading Headlines of THC “overdose”
While most people tout market projections, this CEO notes that many people entering the industry have not considered the logistics behind creating and expanding their business. In such a unique industry, realistic goals and measures will be crucial to long term success and scaling. http://bit.ly/31fJYH0
Benjamin Caplan, MDMarket Projections, Ethanol Extraction, and Mismatched Expectations
After a public hearing on Friday where researchers and health professionals urged the FDA to increase research into cannabis, FDA official Dr. Amy Abernethy tweeted, “We will work as quickly as possible to define a way forward.” The FDA is accepting further comments on a docket until July 2; it then plans to convene a workgroup co-chaired by Abernethy and Lowell Schiller to examine its next steps. http://bit.ly/2WevL9M
Benjamin Caplan, MDFDA Aims to Makes Sense of Medicinal Cannabis”
Israel aims to blaze the way in cannabis research and production, as a leader in biotech with prime land for agriculture. With more relaxed regulation on clinical trials, look to Israel for new studies about cannabis and its benefits. “We are going to write the Torah of cannabis” https://lat.ms/2VYWCX5
Benjamin Caplan, MDIsrael Blazes the Way for Cannabis
A UC Davis study has been testing the effectiveness of a synthetic CBD in treating seizures in rats, and found it to be as effective as the natural compound. In theory, artificially produced cannabinoids could offer great medical benefits, without the need to cultivate cannabis plants. BUT, some synthetics piercing the market are toxic, if not lethal. If the cannabis stigma, based on misinformed understanding, has been difficult to overcome for natural / non-synthetics options, considering the very real damage synthetics have caused, it seems doubtful that they will ever find a way into regular consumption. http://bit.ly/2W44XsQ
Benjamin Caplan, MDUC Davis study investigating synthetic CBD