Non-Cannabis Plant

Medicinal Value of Citrus Peels

Citrus peels waste as a source of value-added compounds: extraction and quantification of bioactive polyphenols

Previous analysis of citrus peels has demonstrated high content of biologically active polyphenols, with significant quantities of flavonoids and phenolic acids present. Both these compounds have been associated with antioxidant, anti-inflammatory, antiproliferative, anti-allergic, antiviral, anticarcinogenic, neuroprotective, and antimicrobial properties.

A recent paper points out that citrus peel waste alone makes up nearly 50% of wet fruit mass discarded as waste and proposes extraction of polyphenols to minimize waste. The bioactive substances in peels can be used in dietary supplements, cosmetics, food products, and pharmaceutical products.

Citrus peels contain significant polyphenols, compounds which have health benefits ranging from antioxidant to anticancer. Polyphenols are also found in large quantities in cannabis, undoubtedly contributing to it many of its well-known health benefits. 

Image result for citrus peel eating

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Benjamin Caplan, MDMedicinal Value of Citrus Peels
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Flavonoid Content and Antioxidant Potential of Fruits, Tubers, and Legumes in the Andean Regions of Ecuador

Chemical composition and Antioxidant Activity of the Main Fruits, Tubers and Legumes Traditionally Consumed in the Andean Regions of Ecuador as a Source of Health-Promoting Compounds

Many fruits grown in the Andean regions of Ecuador have been the center of medical and consumer interests due to their health benefits. Many plants from the region have been used, historically, as both food sources and therapeutic agents. In response to limited studies on the antioxidant capacity and bioactive compounds that make up these food sources, researchers analyzed many commonly consumed fruits, tubers, and legumes. These demonstrated high total flavonoid, phenolic, and anthocyanin content, which can contribute to high antioxidant potential. A range of antioxidant potentials exist, and many fruits possess these high antioxidant potentials.

Note: A high flavonoid content in many food sources grown in the Andean regions of Ecuador contributes to high antioxidant potential in many of these fruits, tubers, and legumes. Many plants, including cannabis, have high flavonoid content that gives them many viable therapeutic applications.

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Benjamin Caplan, MDFlavonoid Content and Antioxidant Potential of Fruits, Tubers, and Legumes in the Andean Regions of Ecuador
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Between Bitter and Sweet Honey, from Algeria Mediterranean Coast, Different Flavonoid Content Contributes to Distinct Antioxidant Potentials

Characteristics of the bitter and sweet honey from Algeria Mediterranean coast

Previous research on honey and its historical use in traditional medicine has pointed toward its therapeutic application for the immune system, anemia, and heart function, among other conditions.

Two kinds of honey harvested from the Algeria Mediterranean coast, so-called poly-floral sweet honey and uni-floral bitter honey, have demonstrated their many medicinal uses. In a comparative analysis of the two kinds of honey, bitter honey had higher flavonoid content, lower sucrose content, and higher total polyphenols and tannins levels, giving it an increased antioxidant potential over sweet honey.

Additional Point: Factors including a higher flavonoid content in uni-floral bitter content gives it an improved antioxidant potential over poly-floral sweet honey. This makes for a wide variety of clinical benefits, including treatment of anemia, colon cancer, improved immune function, and more.

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Benjamin Caplan, MDBetween Bitter and Sweet Honey, from Algeria Mediterranean Coast, Different Flavonoid Content Contributes to Distinct Antioxidant Potentials
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Study Reveals that Flavanoids can act as Allergy Medications

Anti-histaminic Effects of Resveratrol and Silymarin on Human Gingival Fibroblasts

It has recently been revealed that the flavonoids resveratrol and silymarin have an anti-histaminic effect on human gingival fibroblasts (HGF). HGF are cells that compose part of the gum tissue in the oral cavity. Silymarin and resveratrol were already known to have anti-bacterial and anti-inflammatory properties, but a recently published study has now revealed that silymarin alone and a combination of the two flavonoids both provide novel therapeutic approaches for inflammation due to allergies.

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Benjamin Caplan, MDStudy Reveals that Flavanoids can act as Allergy Medications
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Complex Genetics Underlie Cannabinoid Production

Cannabinoid Inheritance Relies on Complex Genetic Architecture

Researchers have recently attempted to discover the genetic basis of cannabinoid production within cannabis plants, finding a complex genetic architecture. This study highlights the lack of knowledge surrounding cannabis cultivation, suggesting current producers record the phenotypic and genetic crosses they breed so that the community can further research the cannabinoids produced. Specifying which genetic profiles match up to the ratio of cannabinoids produced will benefit mass production and medical research.

The introduction of this article focuses heavily on the ratio of ∆-9-tetrahydrocannabinol to cannabidiol, yet there are therapeutic benefits associated with all of the other cannabinoids as well as flavonoids and terpenes produced by the plant. Multiple chemical components of cannabis strains have yet to be fully explored and preliminary findings warrant the same amount of attention in order to develop various therapies.

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Benjamin Caplan, MDComplex Genetics Underlie Cannabinoid Production
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Honey and Garlic Help Heal Burn Wounds

Euphorbia honey and garlic- Biological activity and burn wound recovery

A recent study has shown that a combination of euphorbia honey and garlic can help heal burn wounds. Euphorbia honey and garlic have antioxidant, microbial, and healing properties that have now been confirmed to be effective when treating wounds resulting from exposure to extreme heat. Combining natural ingredients has been common in traditional medicine for years, but now western medicine is beginning to look at more natural compounds to aid in recovery and treatment methods.

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Benjamin Caplan, MDHoney and Garlic Help Heal Burn Wounds
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Recent Study Finds that Astragalin Prevents Tumor Growth

A Kaempferol-3-O-β-D-glucoside, Intervention Effect of Astragalin on Estradiol Metabolism

A recent study found that a flavonoid known as astragalin possesses a strong anti-tumor effect. High levels of a metabolite formed from the hormone estradiol have been found in tumor tissues leading researchers to search for an inhibitor to prevent estradiol from forming the metabolite. This study has found that astragalin, which is a naturally occurring substance found in a variety of plants and wine, has an effective antitumor mechanism that inhibits the formation of the metabolite.

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Benjamin Caplan, MDRecent Study Finds that Astragalin Prevents Tumor Growth
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Flavonoids Found in Buckwheat Hulls Have Antioxidant Properties

Flavonoids in common and Tartary Buckwheat hull extracts and antioxidant activity of the extracts against lipids in mayonnaise

A recent study has revealed that the various flavonoids in buckwheat hulls are a reliable source for antioxidant material. When a buckwheat hull extract was made and exposed to mayonnaise, the shelf-life of the mayonnaise was extended, likely related to the antioxidant properties. This study was able to determine the effectiveness of extracts from the common and Tartary Buckwheat hulls, as well as provide an efficient extraction method.

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Benjamin Caplan, MDFlavonoids Found in Buckwheat Hulls Have Antioxidant Properties
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Compounds in Citrus Peels Functioning as Preventive Agents for Prostate Cancer

Effect of citrus peel extracts on the cellular quiescence of prostate cancer cells

A recent study has revealed that citrus peel extracts (CPE) have the potential to prevent prostate cancer from recurring in post-therapy cancer patients. A component of CPE, flavonoids, have previously been found to have anticancer effects, but appear to lack the correct structure to prevent tumors in patients with prostate cancer. This specific study found that the citric acid present in CPE was the contributing factor to its anticancer effects but mentioned that flavonoids should continue to be researched for chemopreventive benefits.

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Benjamin Caplan, MDCompounds in Citrus Peels Functioning as Preventive Agents for Prostate Cancer
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Flavonoids May Provide Therapeutic Benefits for Type 2 Diabetes

A recent study has found that flavonoids isolated from Psoralea corylifolia are able to inhibit part of the insulin pathway.

Seeds of the P. corylifolia plant have been used in eastern medicine, primary in China, for years, and is now being further researched as flavonoids continue to intrigue researchers with their possible therapeutic benefits. The inhibitory activity found in this study provides evidence that flavonoids should be pursued as a potential treatment for Type-2 Diabetes.

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Benjamin Caplan, MDFlavonoids May Provide Therapeutic Benefits for Type 2 Diabetes
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