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Nutritional Supplements Modulate Cannabinoid Content

Title: Impact of N, P, K and humic acids supplementation on the chemical profile of medical cannabis (Cannabis sativa L)

A recent study has come out revealing the effects of nutritional supplements (plant food) on cannabinoid content during the growth of the cannabis plant.

Researchers enhanced nutritional supplements such as humic acids and inorganic nitrogen and potassium and determined that the changes in supplement levels caused variations in the cannabinoid content of the plant organs. This research has demonstrated that maintaining specific nutritional supplements effects the chemical properties of cannabis plants and may play a role in standardizing the cannabinoid content in plants, no matter the region of growth. This knowledge may one day help cultivators with the process of standardizing cultivars, and perhaps help organize strain names and content across state lines.

This work spotlights the inconsistency between cannabis plants, even if they share the same name. The nutrients cannabis plants grow in have been proven to alter the cannabinoid content which changes (sometimes drastically) the effects felt by patients who consume that plant. Growers or enthusiasts who grow cannabis at home may be buying seeds from a known strain, but the same seeds produce a completely different strain, depending on the growing conditions. Standardizing growth conditions will hopefully help cultivators produce strains of the same name with consistent cannabinoid content, making buying safer and somewhat more uniformly regulatable. 

Tweet: A recent study has come out revealing the effects of #nutritional supplements on #cannabinoid content during #cannabis plant growth. Read this and other linked studies:

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Benjamin Caplan, MDNutritional Supplements Modulate Cannabinoid Content
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Video: Do-It-Yourself Cannabis Tinctures

One of the terrific realities of modern Cannabis is that it is possible, and often quite simple, to make effective products at home. With suitable education and access to testing facilities, the soil, nutrients, and plant growth can be supported at home, lab-tested for make-up and potency, as well as safety-checked for potential microscopic contaminants, and ultimately, individualized medicine can be created right at home!

Here is a sample instructional for just one way that cannabis tincture can be made at home. There are countless others and hopefully, many that are yet to be discovered!

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Benjamin Caplan, MDVideo: Do-It-Yourself Cannabis Tinctures
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Maintain a Balanced Diet when Consuming Oral Cannabidiol

Title: Food effect on pharmacokinetics of cannabidiol oral capsules in adult patients with refractory epilepsy

Researchers have recently revealed the importance of maintaining a balanced diet, when consuming cannabidiol (CBD). Consuming oral capsules containing CBD may be a more consistent method of consumption than blending CBD into liquids or solid foods, but unfortunately, capsules do not prevent a high degree of potential fluctuation of dosing. The fat content of a meal may vary widely, and so may change the active concentrations of CBD which become active in the bloodstream. In other words, the effects felt by a consumer may be either stronger or weaker, and differ in duration, related to the method of consumption, and the product make-up taken. Patients considering CBD as a therapeutic intervention, who also want a consistency of effect, would be wise to be mindful to maintain a diet with a balanced amount of fat (oils, butter, etc.) when consuming CBD capsules. 


This article highlights the variation of effects felt when altering consumption methods. For example, edibles and inhaled cannabinoids of the same dosage have extremely different effects, because of how they are processed in the body processes. When inhaled, tetrahydrocannabinol (THC) diffuses across structures in the lungs known as alveoli, and are then transmitted to circulate throughout the bloodstream. Edibles introduce THC into the system by first metabolizing with liver enzymes, resulting in an altered metabolite of THC circulating throughout the body. This subtly-altered metabolite of THC can be more potent than the starting material, although the onset is delayed due to the process of consumption, digestion, and metabolism. All consumers would do well to research their consumption method of choice and proceed carefully when switching between methods. 

Tweet: Researchers have recently revealed the importance of maintaining a balanced #diet when consuming #cannabidiol (#CBD). Learn more at

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Benjamin Caplan, MDMaintain a Balanced Diet when Consuming Oral Cannabidiol
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Medicinal Value of Citrus Peels

Citrus peels waste as a source of value-added compounds: extraction and quantification of bioactive polyphenols

Previous analysis of citrus peels has demonstrated high content of biologically active polyphenols, with significant quantities of flavonoids and phenolic acids present. Both these compounds have been associated with antioxidant, anti-inflammatory, antiproliferative, anti-allergic, antiviral, anticarcinogenic, neuroprotective, and antimicrobial properties.

A recent paper points out that citrus peel waste alone makes up nearly 50% of wet fruit mass discarded as waste and proposes extraction of polyphenols to minimize waste. The bioactive substances in peels can be used in dietary supplements, cosmetics, food products, and pharmaceutical products.

Citrus peels contain significant polyphenols, compounds which have health benefits ranging from antioxidant to anticancer. Polyphenols are also found in large quantities in cannabis, undoubtedly contributing to it many of its well-known health benefits. 

Image result for citrus peel eating

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Benjamin Caplan, MDMedicinal Value of Citrus Peels
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Between Bitter and Sweet Honey, from Algeria Mediterranean Coast, Different Flavonoid Content Contributes to Distinct Antioxidant Potentials

Characteristics of the bitter and sweet honey from Algeria Mediterranean coast

Previous research on honey and its historical use in traditional medicine has pointed toward its therapeutic application for the immune system, anemia, and heart function, among other conditions.

Two kinds of honey harvested from the Algeria Mediterranean coast, so-called poly-floral sweet honey and uni-floral bitter honey, have demonstrated their many medicinal uses. In a comparative analysis of the two kinds of honey, bitter honey had higher flavonoid content, lower sucrose content, and higher total polyphenols and tannins levels, giving it an increased antioxidant potential over sweet honey.

Additional Point: Factors including a higher flavonoid content in uni-floral bitter content gives it an improved antioxidant potential over poly-floral sweet honey. This makes for a wide variety of clinical benefits, including treatment of anemia, colon cancer, improved immune function, and more.

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Benjamin Caplan, MDBetween Bitter and Sweet Honey, from Algeria Mediterranean Coast, Different Flavonoid Content Contributes to Distinct Antioxidant Potentials
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Israel and the global cannabis market

Some believe that it is difficult to compete with industry giants, such as Tilray and Cronos. But, Israel’s long history of cannabis research and its innovative companies, leading tech and strong agricultural climate make it a likely region to attract many in the global cannabis market. http://bit.ly/2IPXbz8

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Benjamin Caplan, MDIsrael and the global cannabis market
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Honey and Garlic Help Heal Burn Wounds

Euphorbia honey and garlic- Biological activity and burn wound recovery

A recent study has shown that a combination of euphorbia honey and garlic can help heal burn wounds. Euphorbia honey and garlic have antioxidant, microbial, and healing properties that have now been confirmed to be effective when treating wounds resulting from exposure to extreme heat. Combining natural ingredients has been common in traditional medicine for years, but now western medicine is beginning to look at more natural compounds to aid in recovery and treatment methods.

This paper is also stored here:  http://bit.ly/2Fbqk5F   inside the CED Foundation Archive

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Benjamin Caplan, MDHoney and Garlic Help Heal Burn Wounds
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Recent Study Finds that Astragalin Prevents Tumor Growth

A Kaempferol-3-O-β-D-glucoside, Intervention Effect of Astragalin on Estradiol Metabolism

A recent study found that a flavonoid known as astragalin possesses a strong anti-tumor effect. High levels of a metabolite formed from the hormone estradiol have been found in tumor tissues leading researchers to search for an inhibitor to prevent estradiol from forming the metabolite. This study has found that astragalin, which is a naturally occurring substance found in a variety of plants and wine, has an effective antitumor mechanism that inhibits the formation of the metabolite.

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Benjamin Caplan, MDRecent Study Finds that Astragalin Prevents Tumor Growth
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Flavonoids Found in Buckwheat Hulls Have Antioxidant Properties

Flavonoids in common and Tartary Buckwheat hull extracts and antioxidant activity of the extracts against lipids in mayonnaise

A recent study has revealed that the various flavonoids in buckwheat hulls are a reliable source for antioxidant material. When a buckwheat hull extract was made and exposed to mayonnaise, the shelf-life of the mayonnaise was extended, likely related to the antioxidant properties. This study was able to determine the effectiveness of extracts from the common and Tartary Buckwheat hulls, as well as provide an efficient extraction method.

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Benjamin Caplan, MDFlavonoids Found in Buckwheat Hulls Have Antioxidant Properties
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Compounds in Citrus Peels Functioning as Preventive Agents for Prostate Cancer

Effect of citrus peel extracts on the cellular quiescence of prostate cancer cells

A recent study has revealed that citrus peel extracts (CPE) have the potential to prevent prostate cancer from recurring in post-therapy cancer patients. A component of CPE, flavonoids, have previously been found to have anticancer effects, but appear to lack the correct structure to prevent tumors in patients with prostate cancer. This specific study found that the citric acid present in CPE was the contributing factor to its anticancer effects but mentioned that flavonoids should continue to be researched for chemopreventive benefits.

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Benjamin Caplan, MDCompounds in Citrus Peels Functioning as Preventive Agents for Prostate Cancer
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