All posts tagged: Addiction

Development of Cannabis-Based Treatment for Bipolar Disorder

Bipolar disorder and the endocannabinoid system

A recently published article serves as a call for research to be conducted to discover how cannabis could impact the management of bipolar disorder (BD). Presented in the article is a full review of the advantages and disadvantages of cannabis-based medicine in the treatment of BD and provides insight into possible mechanisms might affect the pathophysiology of the disorder. The insights listed within the article provide the rationale for examining the endocannabinoid system, specifically the cannabinoid receptor 2, with the hopes of finding therapeutic targets for mood control associated with BD.  

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This paper is also stored here:   http://bit.ly/2FfJXK6      inside the CED Foundation Archive

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Benjamin Caplan, MDDevelopment of Cannabis-Based Treatment for Bipolar Disorder
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Looking for a genetic explanation for “Cannabis Use Disorder”

Genome-wide association study implicates CHRNA2 in Cannabis Use Disorder

Roughly 9% of cannabis users become dependent. In a recent study, scientists identified a significant association between CHRNA2 gene expression and a diagnosis of Cannabis Use Disorder. In other words, genetics might help to explain why some people may find themselves more dependent upon cannabis than others.

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This paper is also stored here:    http://bit.ly/2IVZJvJ     inside the CED Foundation Archive

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Benjamin Caplan, MDLooking for a genetic explanation for “Cannabis Use Disorder”
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The Cannabinoid System is a Promising Source of Targets for Treating Pain

A Budding Source of Targets for Treating Inflammatory and Neuropathic Pain ECS

The cannabinoid system provides momentum to develop cannabinoid-based medications to treat inflammatory and neuropathic pain as researchers continue to find promising therapeutic targets. These new targets may lead to the formation of novel pain-relief medications that may serve well to alleviate pain for those suffering from cancer, multiple sclerosis, and fibromyalgia. Cannabis-based pain medicine is also being researched for opioid-sparing effects and effectiveness in reducing the necessary dose of opioids.

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This paper is also stored here:  http://bit.ly/2FfLorA        inside the CED Foundation Archive

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Benjamin Caplan, MDThe Cannabinoid System is a Promising Source of Targets for Treating Pain
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Medical vs Rec

Many think medical marijuana laws will ultimately lead to adult-use, but this is not necessarily true, and for good reason. The medical industry recognizes that cannabis is a powerful medication and prioritizes its safety and health benefits, while so-called “recreational” or “adult use” cannabis seems to focus more on making money and supporting the pleasurable aspects of the plant.

Interestingly, at CED Clinic, we’re seeing more and more patients come in from the “adult-use.” Whether it’s a desire for comprehensive education (anything we put into our bodies has effects), personalizing a medical plan that considers short-term and long-term impact, or simply having a knowledgeable person to support individual choices and empowerment on an individual journey, we find that our patients enjoy learning and riding the cutting edge of the science of cannabis! http://bit.ly/2INDGY7

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Benjamin Caplan, MDMedical vs Rec
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Variations in Genes Influences Cannabis’ Acute Effects on Behavior

CNR1 and FAAH variation and affective states induced by marijuana smoking

A recent study has revealed that variations within cannabinoid receptor 1 (CBR1) and fatty acid amide hydrolase (FAAH) influences cannabis’ acute effects on affect. Variations of CBR1 and FAAH are known to be associated with cannabis dependence. The current study now adds that the variations in genes also affect an individual’s behavior when ingesting cannabis. The results of this study provide useful information for understanding an individual’s motivation for marijuana use, as well as risks and associated behaviors.

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This paper is also stored here:   http://bit.ly/31Ce9Za     inside the CED Foundation Archive

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Benjamin Caplan, MDVariations in Genes Influences Cannabis’ Acute Effects on Behavior
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Oncologists Communication with Chronic Medical Cannabis Users

Long-term medical cannabis use and risk factors for diversion- report on physician’s guidance and patients’ behaviour

A recent examination of long-term medical cannabis users has demonstrated the need for more consistent training of storage and disposal practices from oncologists. Chronic users tend to increase the dosage taken of medical cannabis over time due to tolerance; higher doses of cannabis are associated with dangerous storage and disposal practices. The current study calls for oncologists who recommend cannabis-based medicine to their patients to have more consistent training in safe storage and disposal methods to prevent patients from ingesting or giving away impure cannabis.

An important point brought up in this article is the pressure some patients experience from their peers to buy cannabis for multiple people with their medical marijuana identification card or certification. Physicians should be wary of this practice and support their patients, reminding them of the accidents that can happen when medications are shared.

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Benjamin Caplan, MDOncologists Communication with Chronic Medical Cannabis Users
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Recently Identified Mechanism of Chronic Stress-Induced Pain

Chronic Stress Is Associated with Pain Precipitation and Elevation in DeltaFosb Expression

Researchers have identified Delta-FosB, an osteosarcoma viral oncogene, as a useful molecular marker of sustained pain. The expression of Delta-FosB is significantly elevated by stress-induced pain, exposing its role in the adaptability of nerves. This study supports theories that Delta-FosB plays an important role in drug addiction, depression, and stress adaptation. The interaction between stress, depression, and pain is something that is not yet well-understood. But, as we learn more about cannabis-based medicine, many of the age-old questions about pain have become much clearer.

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This paper is also stored here:   http://bit.ly/31A7Y86      inside the CED Foundation Archive

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Benjamin Caplan, MDRecently Identified Mechanism of Chronic Stress-Induced Pain
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Cannabinoid Receptors Working with Opioid Receptors

The locus coeruleus is a spot in the human brainstem that is integral to our responses to stress, panic, wakefulness, and sleep-wake transitions. Both the cannabinoid receptors and opioid receptors in the locus coeruleus have a synergistic relationship that, once the medical system begins to incorporate more education about cannabinoids, just might change how physicians prescribe pain medication. The interactions of the two receptor types provide a mechanism that could easily and conveniently improve pain control, provide treatments for addiction, and will likely aid those experiencing symptoms of withdrawal. Research focusing on the treatment of opioid addiction with cannabis is ongoing… but hindered by the legal status of cannabis.

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This paper is also stored here:     http://bit.ly/2MMeYeK    inside the CED Foundation Archive

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Benjamin Caplan, MDCannabinoid Receptors Working with Opioid Receptors
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Adolescent Executive Dysfunction in Daily Life: Relationships to Risks, Brain Structure and Substance Use

Researchers assessed 817 youth (aged 12 to 21) who previously participated in the National Consortium on Alcohol and Neurodevelopment in Adolescence study. They found that 123 subjects (15.2%) had used cannabis in the past year, and that cannabis use impaired inhibitory control, emotional control, and task planning.

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This paper is also stored here:    http://bit.ly/2L0aMWa     inside the CED Foundation Archive

Benjamin Caplan, MDAdolescent Executive Dysfunction in Daily Life: Relationships to Risks, Brain Structure and Substance Use
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A Call for Physicians to Embrace Medicinal Cannabis as a Virtuoso of Prudence

The Prescription of Medicinal Cannabis and the Virtue of Prudence: Without Phobia(S) Nor Philia(S)

A passionate physician shared his opinion on prescribing patients medicinal cannabis, promoting its use in accordance with the virtue of prudence. The piece implores physicians to identify the medicinal benefits of cannabis and embrace its side effects without fear. Medicinal cannabis has its place among prescriptions with “respect for leges artis” as long as the decision to recommend cannabis is the result of an ethical-clinically based decision.  

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This paper is also stored here:     http://bit.ly/2Ff3mLc    inside the CED Foundation Archive

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Benjamin Caplan, MDA Call for Physicians to Embrace Medicinal Cannabis as a Virtuoso of Prudence
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